Western Blot (WB)
(APOL1-BH3 Domain Antibody (MBS9210552) western blot analysis in U937 cell line lysates (35ug/lane).This demonstrates the APOL1-BH3 Domain antibody detected the APOL1-BH3 Domain protein (arrow).)
Rabbit anti-Human APOL1 Polyclonal Antibody | anti-APOL1 antibody
APOL1 Antibody
IHC-P~~1:10~50
FC~~1:10~50
Western Blot (WB)
(APOL1-BH3 Domain Antibody (MBS9210552) western blot analysis in U937 cell line lysates (35ug/lane).This demonstrates the APOL1-BH3 Domain antibody detected the APOL1-BH3 Domain protein (arrow).)
Western Blot (WB)
(APOL1-BH3 Domain Antibody (MBS9210552) western blot analysis in U937 cell line lysates (35ug/lane).This demonstrates the APOL1-BH3 Domain antibody detected the APOL1-BH3 Domain protein (arrow).)
Immunohistochemistry (IHC)
(APOL1 Antibody (MBS9210552) IHC analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the APOL1 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(APOL1 Antibody (MBS9210552) IHC analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the APOL1 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.)
Flow Cytometry (FC/FACS)
(APOL1 Antibody (19169) FC analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(APOL1 Antibody (19169) FC analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Zhaorigetu,S., Autophagy 4 (8), 1079-1082 (2008)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Uniprot Description
APOL1: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomerulosclerosis type 4 (FSGS4). It is a renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Belongs to the apolipoprotein L family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid-binding; Secreted, signal peptide; Secreted; Channel, chloride
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: extracellular space; extracellular region; intrinsic to membrane
Molecular Function: chloride channel activity; protein binding; lipid binding
Biological Process: receptor-mediated endocytosis; cholesterol metabolic process; killing of cells of another organism; cytolysis; innate immune response; lipoprotein metabolic process; chloride transport; lipid transport
Disease: Focal Segmental Glomerulosclerosis 4, Susceptibility To
Research Articles on APOL1
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Product Notes
The APOL1 apol1 (Catalog #AAA9210552) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 137-171. The APOL1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's APOL1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Western Blot (WB). WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50. Researchers should empirically determine the suitability of the APOL1 apol1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APOL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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