Rabbit anti-Human APOE/Apolipoprotein E Polyclonal Antibody | anti-APOE antibody

Anti-APOE/Apolipoprotein E Antibody (C-Terminus)

Cat. Num. AAA2401344

• Gene Names: APOE; AD2; LPG; APO-E; ApoE4; LDLCQ5
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Ammonium sulfate precipitation
• Synonyms: APOE/Apolipoprotein E; Polyclonal Antibody; Anti-APOE/Apolipoprotein E Antibody (C-Terminus); Mouse Monoclonal (IgG1) to Human APOE/Apolipoprotein E; APOE; AD2; Apo-E; Apolipoprotein E3; Apolipoprotein E; LDLCQ5; LPG; anti-APOE antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human APOE/Apolipoprotein E
• Purity/Purification: Ammonium sulfate precipitation
• Form/Format: PBS, 0.09% sodium azide.
• Sequence Length: 317

• Applicable Applications for anti-APOE antibody: Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: IHC-P: 1:100; WB: 1:1000
• Immunogen: This APOE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human APOE.
• Conjugation: Unconjugated
• Epitope: C-Terminus
• Preparation and Storage: Short term: -20 degree C; Long term: -20 degree C.

Immunohistochemistry (IHC)

(Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-APOE antibody

Chylomicron remnants and very low density lipoprotein (VLDL) remnantsare rapidly removed from the circulation by receptor-mediatedendocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheralcells. ApoE is essential for the normal catabolism of triglyceride-richlipoprotein constituents. the APOE gene is mapped to chromosome 19 in acluster with APOC1 and APOC2.

NCBI and Uniprot Product Information

• NCBI GI #: 4557325
• NCBI GeneID: 348
• NCBI Accession #: NP_000032.1
• NCBI GenBank Nucleotide #: NM_000041.3
• UniProt Accession #: P02649; Q9P2S4; B2RC15; C0JYY5
• Molecular Weight: 36,154 Da
• NCBI Official Full Name: apolipoprotein E isoform b
• NCBI Official Synonym Full Names: apolipoprotein E
• NCBI Official Symbol: APOE
• NCBI Official Synonym Symbols: AD2; LPG; APO-E; ApoE4; LDLCQ5
• NCBI Protein Information: apolipoprotein E
• UniProt Protein Name: Apolipoprotein E
• Protein Family: Apolipoprotein
• UniProt Gene Name: APOE
• UniProt Synonym Gene Names: Apo-E

NCBI Description

The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]

Uniprot Description

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.