APOBEC3D/F Polyclonal Antibody | anti-APOBEC3D/F antibody

APOBEC3D/F Polyclonal Antibody

Cat. Num. AAA8521252

• Gene Names: APOBEC3D; A3D; ARP6; APOBEC3E; APOBEC3DE
• Synonyms: APOBEC3D/F; Polyclonal Antibody; APOBEC3D/F Polyclonal Antibody; anti-APOBEC3D/F antibody

• Clonality: Polyclonal
• Sequence Length: 386

NCBI and Uniprot Product Information

• NCBI GI #: 48474596
• NCBI GeneID: 140564
• UniProt Accession #: Q96AK3; Q5JZ91; Q7Z2N2; Q7Z2N5; Q7Z2N6
• Molecular Weight: 46,598 Da
• NCBI Official Full Name: DNA dC->
• NCBI Official Synonym Full Names: apolipoprotein B mRNA editing enzyme catalytic subunit 3D
• NCBI Official Symbol: APOBEC3D
• NCBI Official Synonym Symbols: A3D; ARP6; APOBEC3E; APOBEC3DE
• NCBI Protein Information: DNA dC->dU-editing enzyme APOBEC-3D
• UniProt Protein Name: DNA dC->dU-editing enzyme APOBEC-3D
• UniProt Gene Name: APOBEC3D
• UniProt Synonym Gene Names: A3D

NCBI Description

This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. [provided by RefSeq, Jul 2008]

Uniprot Description

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.