Rabbit anti-Human APOBEC3C Polyclonal Antibody | anti-APOBEC3C antibody

APOBEC3C Antibody (C-Term)

Cat. Num. AAA9217307

• Gene Names: APOBEC3C; A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3
• Reactivity: Human
• Applications: Western Blot, ELISA
• Synonyms: APOBEC3C; Polyclonal Antibody; APOBEC3C Antibody (C-Term); DNA dC->dU-editing enzyme APOBEC-3C; A3C; 3.5.4.-; APOBEC1-like; Phorbolin I; APOBEC1L; PBI; anti-APOBEC3C antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This APOBEC3C antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 143-177 amino acids from human APOBEC3C.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 190

• Applicable Applications for anti-APOBEC3C antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB:~~1:2000
• Subtitle: Purified Rabbit Polyclonal Antibody (Pab)
• Cellular Location: Nucleus. Cytoplasm.
• Tissue Location: Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary.
• Antigen Type: Synthesized Peptide
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Anti-APOBEC3C Antibody (C-Term) at 1:2000 dilution + PC-3 whole cell lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 23 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-APOBEC3C antibody

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Product Categories/Family for anti-APOBEC3C antibody

Primary Antibodies; Immunology

References

Gu J.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases. Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11 (2004). Ota T.,et al.Nat. Genet. 36:40-45 (2004). Dunham I.,et al.Nature 402:489-495 (1999). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

NCBI and Uniprot Product Information

• NCBI GI #: 22907039
• NCBI GeneID: 27350
• NCBI Accession #: NP_055323.2
• NCBI GenBank Nucleotide #: NM_014508.2
• UniProt Accession #: Q9NRW3; Q5JZ92; Q7Z2N7; Q96F12; B2R884
• Molecular Weight: 22826 Da
• NCBI Official Full Name: DNA dC->dU-editing enzyme APOBEC-3C
• NCBI Official Synonym Full Names: apolipoprotein B mRNA editing enzyme catalytic subunit 3C
• NCBI Official Symbol: APOBEC3C
• NCBI Official Synonym Symbols: A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3
• NCBI Protein Information: DNA dC->dU-editing enzyme APOBEC-3C
• UniProt Protein Name: DNA dC->dU-editing enzyme APOBEC-3C
• Protein Family: DNA dC->dU-editing enzyme
• UniProt Gene Name: APOBEC3C
• UniProt Synonym Gene Names: APOBEC1L; PBI; A3C
• UniProt Entry Name: ABC3C_HUMAN

NCBI Description

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]

Uniprot Description

APOBEC3C: Host cellular restriction factor that may have antiviral activities against exogenous and endogenous viruses, as well as retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Belongs to the cytidine and deoxycytidylate deaminase family.

Protein type: EC 3.5.4.-; RNA-binding; Hydrolase

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: cytoplasm; nucleus

Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; protein binding; zinc ion binding

Biological Process: cytidine deamination; defense response to virus; innate immune response; negative regulation of viral genome replication; viral reproduction