Goat anti-Human APOA2 Polyclonal Antibody | anti-APOA2 antibody

APOA2 (Apolipoprotein A-II, Apo-AII, ApoA-II, Apolipoprotein A2) (PE)

Cat. Num. AAA6444544

• Gene Names: APOA2; apoAII; Apo-AII; ApoA-II
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA, Western Blot, Immunoprecipitation
• Purity: Purified by Immunoaffinity chromatography.
• Synonyms: APOA2; Polyclonal Antibody; APOA2 (Apolipoprotein A-II; Apo-AII; ApoA-II; Apolipoprotein A2) (PE); anti-APOA2 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Apolipoprotein A-II. Negligible cross reactivity to Apo A-I, B, C-I, C-II, C-III, E and J by ELISA. Negligible non-specific cross reaction with other human serum proteins.
• Purity/Purification: Purified by Immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-APOA2 antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: IHC: 1:50-1:200; ELISA: 1:4,000-1:8000; WB: 1:5000-1:10,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide corresponding to Apolipoprotein A-II.
• Conjugate: PE
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-APOA2 antibody

Antibodies; Lipoproteins

References

1. Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletion. Robert C Rostomily, Donald E Born, Richard P Beyer, Jinghua Jin, Ellsworth C Alvord, Andrei M Mikheev, Russell T Matthews, Catherine Pan, Leila Khorasani, Josh A Sonnen, Thomas J Montine, Min Shi, Jing Zhang (2010). Journal of proteome research.9.

NCBI and Uniprot Product Information

• NCBI GI #: 4502149
• NCBI GeneID: 336
• NCBI Accession #: NP_001634.1
• NCBI GenBank Nucleotide #: NM_001643.1
• UniProt Accession #: P02652; B2R524
• Molecular Weight: 11,175 Da
• NCBI Official Full Name: apolipoprotein A-II preproprotein
• NCBI Official Synonym Full Names: apolipoprotein A-II
• NCBI Official Symbol: APOA2
• NCBI Official Synonym Symbols: apoAII; Apo-AII; ApoA-II
• NCBI Protein Information: apolipoprotein A-II; apolipoprotein A2
• UniProt Protein Name: Apolipoprotein A-II
• Protein Family: Apolipoprotein
• UniProt Gene Name: APOA2
• UniProt Synonym Gene Names: Apo-AII; ApoA-II
• UniProt Entry Name: APOA2_HUMAN

NCBI Description

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

Uniprot Description

APOA2: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. Belongs to the apolipoprotein A2 family.

Protein type: Endoplasmic reticulum; Secreted, signal peptide; Secreted; Lipid-binding

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: chylomicron; endoplasmic reticulum lumen; early endosome; extracellular region; cytosol

Molecular Function: lipid transporter activity; protein binding; protein homodimerization activity; lipase inhibitor activity; protein heterodimerization activity; cholesterol transporter activity; cholesterol binding; phospholipid binding; phosphatidylcholine binding; lipid binding; high-density lipoprotein binding; apolipoprotein receptor binding

Biological Process: positive regulation of catalytic activity; phototransduction, visible light; viral reproduction; protein folding; negative regulation of cholesterol transport; response to glucocorticoid stimulus; regulation of protein stability; diacylglycerol catabolic process; positive regulation of lipid catabolic process; cellular lipid metabolic process; negative regulation of lipase activity; negative regulation of lipid catabolic process; regulation of cholesterol absorption; phospholipid efflux; response to glucose stimulus; retinoid metabolic process; response to drug; cholesterol metabolic process; organ regeneration; protein amino acid oxidation; phospholipid catabolic process; positive regulation of interleukin-8 biosynthetic process; cholesterol efflux; lipoprotein metabolic process; negative regulation of cytokine secretion during immune response; cholesterol homeostasis; triacylglycerol metabolic process; reverse cholesterol transport; response to estrogen stimulus; peptidyl-methionine modification; phosphatidylcholine biosynthetic process; acute inflammatory response

Disease: Hypercholesterolemia, Familial