Western Blot (WB)
(WB Suggested Anti-Apoa1 AntibodyTitration: 1.0 ug/mlPositive Control: Rat Muscle)
Rabbit Apoa1 Polyclonal Antibody | anti-APOA1 antibody
Apoa1 antibody - N-terminal region
Western Blot (WB)
(WB Suggested Anti-Apoa1 AntibodyTitration: 1.0 ug/mlPositive Control: Rat Muscle)
Western Blot (WB)
(WB Suggested Anti-Apoa1 AntibodyTitration: 1.0 ug/mlPositive Control: Rat Muscle)
Target Description: Apoa1 is a major component of high density lipoprotein (HDL) that is involved in intercellular cholesterol transport in astrocytes; cofactor for lecithin cholesterolacyltransferase (LCAT)。
NCBI and Uniprot Product Information
NCBI Description
major component of high density lipoprotein (HDL) that is involved in intercellular cholesterol transport in astrocytes; cofactor for lecithin cholesterolacyltransferase (LCAT) [RGD, Feb 2006]
Uniprot Description
APOA1: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. Belongs to the apolipoprotein A1/A4/E family.
Protein type: G protein, monomeric, non-Rab; Cell development/differentiation; Transporter; Inhibitor; Endoplasmic reticulum; Vesicle; Motility/polarity/chemotaxis; Lipid-binding; Secreted; Secreted, signal peptide
Cellular Component: cell surface; chylomicron; cytoplasmic vesicle; endocytic vesicle; extracellular region; extracellular space; nucleus
Molecular Function: apolipoprotein A-I receptor binding; apolipoprotein receptor binding; beta-amyloid binding; chemorepellent activity; cholesterol binding; cholesterol transporter activity; enzyme binding; high-density lipoprotein binding; identical protein binding; lipase inhibitor activity; lipid binding; lipid transporter activity; phosphatidylcholine binding; phospholipid binding; phospholipid transporter activity
Biological Process: adrenal gland development; axon regeneration; axon regeneration in the peripheral nervous system; blood vessel endothelial cell migration; cholesterol biosynthetic process; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; endothelial cell proliferation; G-protein coupled receptor protein signaling pathway; glucocorticoid metabolic process; integrin-mediated signaling pathway; lipoprotein biosynthetic process; lipoprotein metabolic process; negative chemotaxis; negative regulation of cytokine secretion during immune response; negative regulation of heterotypic cell-cell adhesion; negative regulation of hydrolase activity; negative regulation of inflammatory response; negative regulation of interleukin-1 beta secretion; negative regulation of lipase activity; organ regeneration; peptidyl-methionine modification; phosphatidylcholine biosynthetic process; phosphatidylcholine metabolic process; phospholipid efflux; phospholipid homeostasis; phospholipid metabolic process; phospholipid transport; positive regulation of fatty acid biosynthetic process; positive regulation of hydrolase activity; positive regulation of lipoprotein lipase activity; positive regulation of Rho protein signal transduction; positive regulation of stress fiber formation; protein amino acid oxidation; protein localization; protein stabilization; regulation of Cdc42 protein signal transduction; regulation of cholesterol absorption; regulation of protein amino acid phosphorylation; response to drug; response to estrogen stimulus; response to nutrient; reverse cholesterol transport; sequestering of lipid; transforming growth factor beta receptor signaling pathway; triacylglycerol catabolic process; vitamin transport
Research Articles on APOA1
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Product Notes
The APOA1 apoa1 (Catalog #AAA3211572) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Apoa1 antibody - N-terminal region reacts with Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Apoa1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the APOA1 apoa1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: LVFLTGCQAW EFWQQDEPQS QWDRVKDFAT VYVDAVKDSG RDYVSQFESS. It is sometimes possible for the material contained within the vial of "Apoa1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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