Western Blot (WB)
(Western blot analysis of extracts of various cell lines using APLP1 Polyclonal Antibody at dilution of 1:1000.)
Rabbit APLP1 Polyclonal Antibody | anti-APLP1 antibody
APLP1 Polyclonal Antibody
IHC: 1:50-1:100
Western Blot (WB)
(Western blot analysis of extracts of various cell lines using APLP1 Polyclonal Antibody at dilution of 1:1000.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines using APLP1 Polyclonal Antibody at dilution of 1:1000.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human colon carcinoma using APLP1 Polyclonal Antibody at dilution of 1:100 (40x lens).)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human colon carcinoma using APLP1 Polyclonal Antibody at dilution of 1:100 (40x lens).)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Mouse heart using APLP1 Polyclonal Antibody at dilution of 1:100 (40x lens).)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Mouse heart using APLP1 Polyclonal Antibody at dilution of 1:100 (40x lens).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
APLP1: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. Belongs to the APP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; integral to membrane; plasma membrane; basement membrane
Molecular Function: heparin binding; identical protein binding; protein binding; alpha-2C adrenergic receptor binding; transition metal ion binding; alpha-2B adrenergic receptor binding; alpha-2A adrenergic receptor binding
Biological Process: regulation of translation; nervous system development; negative regulation of cAMP biosynthetic process; organ morphogenesis; extracellular matrix organization and biogenesis; apoptosis; forebrain development; mRNA polyadenylation; endocytosis; G-protein signaling, adenylate cyclase inhibiting pathway; cell adhesion
Research Articles on APLP1
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Product Notes
The APLP1 aplp1 (Catalog #AAA2566316) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APLP1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's APLP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:50-1:100. Researchers should empirically determine the suitability of the APLP1 aplp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APLP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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