Western Blot (WB)
(Anti-Apelin antibody, MBS175524, Western blottingWorking concentration of primary antibody: 0.5ug/ml; 40ug protein was loaded.Lane 1: U87 Cell LysateLane 2: MCF-7 Cell LysateLane 3: HELA Cell LysateLane 4: MM453 Cell Lysate )
Rabbit Apelin Polyclonal Antibody | anti-APLN antibody
Anti-Apelin antibody
Predicted to work with: Mouse
Predicted to work with: Mouse
Concentration: 0.1-0.5ug/mL
Tested Species: Human , Rat
Predicted Species: Mouse
Tested Species : In house tested species with positive results
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested
Optimal dilutions should be determined by the end researcher.
Western Blot (WB)
(Anti-Apelin antibody, MBS175524, Western blottingWorking concentration of primary antibody: 0.5ug/ml; 40ug protein was loaded.Lane 1: U87 Cell LysateLane 2: MCF-7 Cell LysateLane 3: HELA Cell LysateLane 4: MM453 Cell Lysate )
Western Blot (WB)
(Anti-Apelin antibody, MBS175524, Western blottingWorking concentration of primary antibody: 0.5ug/ml; 40ug protein was loaded.Lane 1: U87 Cell LysateLane 2: MCF-7 Cell LysateLane 3: HELA Cell LysateLane 4: MM453 Cell Lysate )
Background: Apelin is a neuropeptide expressed in the supraoptic and paraventricular nuclei that acts on specific receptors located on vasopressinergic neurons. The apelin gene to Xq25-q26.3 based on sequence similarity between the apelin sequence and a chromosome X PAC clone. This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010]
Uniprot Description
apelin: Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior. Belongs to the apelin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: Xq25
Cellular Component: extracellular space; extracellular region
Molecular Function: G-protein-coupled receptor binding; hormone activity; apelin receptor binding; receptor binding
Biological Process: lactation; immune response; signal transduction
Research Articles on APLN
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Product Notes
The APLN apln (Catalog #AAA175524) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Apelin antibody reacts with Reacts with: Human, Rat Predicted to work with: Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Apelin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: Concentration: 0.1-0.5ug/mL Tested Species: Human, Rat Predicted Species: Mouse Tested Species : In house tested species with positive results Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested Optimal dilutions should be determined by the end researcher. Researchers should empirically determine the suitability of the APLN apln for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Apelin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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