Rabbit anti-Human, Mouse APBA1 Polyclonal Antibody | anti-APBA1 antibody
APBA1 Rabbit pAb
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]
Uniprot Description
APBA1: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 9q21.12
Cellular Component: Golgi apparatus; synaptic vesicle; protein complex; perinuclear region of cytoplasm; plasma membrane; nucleus
Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; beta-amyloid binding; protein complex binding; PDZ domain binding
Biological Process: intracellular protein transport; synaptic transmission; nervous system development; glutamate secretion; regulation of gene expression; in utero embryonic development; multicellular organism growth; gamma-aminobutyric acid secretion; axon cargo transport; locomotory behavior; protein complex assembly; cell adhesion
Research Articles on APBA1
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Product Notes
The APBA1 apba1 (Catalog #AAA8537978) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APBA1 Rabbit pAb reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's APBA1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 500-2000. Researchers should empirically determine the suitability of the APBA1 apba1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APBA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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