Rabbit APBA1 Polyclonal Antibody | anti-APBA1 antibody

Anti-APBA1 Antibody

Cat. Num. AAA415668

• Gene Names: Apba1; Mint1
• Reactivity: Human. Not yet tested in other species
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: APBA1; Polyclonal Antibody; Anti-APBA1 Antibody; anti-APBA1 antibody

• Host: Rabbit
• Reactivity: Human. Not yet tested in other species
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 839

• Applicable Applications for anti-APBA1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Peptide ELISA titer: 1:5,000-1:20,000; Immunohistochemistry: 1:100-500; Optimal dilutions/concentrations should be determined by the end user
• Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
• Immunogen: Rabbit polyclonal APBA1 antibody was raised against a 14 amino acid peptide from the intermediate residues of human APBA1.
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Immunohistochemistry (IHC)

Related Product Information for anti-APBA1 antibody

This gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]

References

(1) Borg, J.P., et al. The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. Mol. Cell. Biol.1996;16(11):6229-6241.

NCBI and Uniprot Product Information

• NCBI GI #: 13929100
• NCBI GeneID: 83589
• NCBI Accession #: NP_113967.1
• NCBI GenBank Nucleotide #: NM_031779.2
• Molecular Weight: 91,413 Da
• NCBI Official Full Name: amyloid beta A4 protein-binding family A member 1
• NCBI Official Synonym Full Names: amyloid beta (A4) precursor protein-binding, family A, member 1
• NCBI Official Symbol: Apba1
• NCBI Official Synonym Symbols: Mint1
• NCBI Protein Information: amyloid beta A4 precursor protein-binding family A member 1; adapter protein X11alpha; amyloid beta (A4) precursor protein-binding family A APBA1: amyloid beta (A4) precursor protein-binding family A member 1 (X11); amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11); mint-1; neuron-specific X11 protein; neuronal Munc18-1-interacting protein 1
• UniProt Protein Name: Amyloid beta A4 precursor protein-binding family A member 1
• Protein Family: Amyloid beta A4 precursor protein-binding family
• UniProt Gene Name: Apba1
• UniProt Entry Name: APBA1_RAT

NCBI Description

component of multimeric complex containing Munc18-1 and syntaxin; may mediate synaptic vesicle docking/fusion [RGD, Feb 2006]

Uniprot Description

APBA1: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.

Protein type: Adaptor/scaffold

Cellular Component: Golgi apparatus; protein complex; membrane; cell; perinuclear region of cytoplasm; plasma membrane; intracellular; nucleus

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; beta-amyloid binding; protein complex binding; PDZ domain binding

Biological Process: intracellular protein transport; synaptic transmission; synaptic vesicle exocytosis; glutamate secretion; regulation of gene expression; in utero embryonic development; multicellular organism growth; gamma-aminobutyric acid secretion; locomotory behavior