Rabbit anti-Human AP1AR Polyclonal Antibody | anti-AP1AR antibody
AP1AR Antibody
Gene Names
AP1AR; 2C18; GBAR; C4orf16; PRO0971; gamma-BAR
Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
AP1AR; Polyclonal Antibody; AP1AR Antibody; 2c18; Adapter-related protein complex 1-associated regulatory protein; AP-1 complex-associated regulatory protein; AP1AR_HUMAN; C4orf16; Chromosome 4 open reading frame 16; Gamma-1-adaptin brefeldin A resistance protein; Gamma-BAR; Gamma1-adaptin brefeldin A resistance protein; gamma-BAR; GBAR; PRO0971; anti-AP1AR antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
AP1AR Antibody detects endogenous levels of AP1AR.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-AP1AR antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human AP1AR.
Conjugation
Unconjugated
Post Translational Modifications
Palmitoylated.
Subunit Structure
Interacts (via coiled-coil domain) with AP1G1 (via GAE domain). Interacts with KIF5B. Associates with the Arp2/3 complex.
Function
Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.
Note
Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-AP1AR antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
30,459 Da
NCBI Official Full Name
AP-1 complex-associated regulatory protein isoform b
NCBI Official Synonym Full Names
adaptor-related protein complex 1 associated regulatory protein
NCBI Official Symbol
AP1AR
NCBI Official Synonym Symbols
2C18; GBAR; C4orf16; PRO0971; gamma-BAR
NCBI Protein Information
AP-1 complex-associated regulatory protein; adapter-related protein complex 1-associated regulatory protein; adaptor-related protein complex 1-associated regulatory protein; gadkin; gamma-1-adaptin brefeldin A resistance protein; gamma-A1-adaptin and kine
UniProt Protein Name
AP-1 complex-associated regulatory protein
Protein Family
UniProt Gene Name
AP1AR
UniProt Synonym Gene Names
C4orf16; GBAR; Gamma-BAR; Gadkin
UniProt Entry Name
AP1AR_HUMAN
Uniprot Description
AP1AR: Necessary for AP-1 dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/Gamma1-adaptin, one of the subunits of the AP-1 adapter complex. The direct interaction with AP1G1/Gamma1- adaptin attenuates the release of the AP-1 complex from membranes. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: Golgi apparatus; transport vesicle; late endosome; early endosome
Molecular Function: kinesin binding
Biological Process: protein transport; negative regulation of receptor recycling; vesicle targeting, trans-Golgi to endosome
Research Articles on AP1AR
Similar Products
Product Notes
The AP1AR ap1ar (Catalog #AAA9630457) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AP1AR Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's AP1AR can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the AP1AR ap1ar for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AP1AR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
