Rabbit anti-Human AP-1 complex subunit sigma-3 Polyclonal Antibody | anti-AP1S3 antibody

Rabbit anti-human AP-1 complex subunit sigma-3 polyclonal Antibody

Cat. Num. AAA1490415

• Gene Names: AP1S3; PSORS15
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Synonyms: AP-1 complex subunit sigma-3; Polyclonal Antibody; Rabbit anti-human AP-1 complex subunit sigma-3 polyclonal Antibody; Adapter-related protein complex 1 sigma-1C subunit Adaptor protein complex AP-1 sigma-1C subunit Clathrin assembly protein complex 1 sigma-1C small chain Golgi adaptor HA1/AP1 adaptin sigma-1C subunit Sigma 1C subunit of AP-1 clathrin Sigma-adaptin 1; anti-AP1S3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Sequence Length: 154

• Applicable Applications for anti-AP1S3 antibody: ELISA (EIA), Western Blot (WB)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Non-conjugated
• Immunogen: Recombinant human AP-1 complex subunit sigma-3 protein
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: AP-1 complex subunit sigma-3 antibody at 2ug/ml+A549 whole cell lysateSecondaryGoat polyclonal to Rabbit IgG at 1/10000 dilutionPredicted band size: 19,20,13 kDaObserved band size: 18 kDa)

Related Product Information for anti-AP1S3 antibody

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

NCBI and Uniprot Product Information

• NCBI GI #: 88703051
• NCBI GeneID: 130340
• NCBI Accession #: NP_001034658.1
• NCBI GenBank Nucleotide #: NM_001039569.1
• UniProt Accession #: Q96PC3; Q8WTY1; Q96DD1; B4DQZ1
• Molecular Weight: 12,655 Da
• NCBI Official Full Name: AP-1 complex subunit sigma-3
• NCBI Official Synonym Full Names: adaptor related protein complex 1 sigma 3 subunit
• NCBI Official Symbol: AP1S3
• NCBI Official Synonym Symbols: PSORS15
• NCBI Protein Information: AP-1 complex subunit sigma-3
• UniProt Protein Name: AP-1 complex subunit sigma-3
• Protein Family: AP-1 complex
• UniProt Gene Name: AP1S3
• UniProt Entry Name: AP1S3_HUMAN

NCBI Description

This gene encodes a member of the adaptor-related protein complex 1, sigma subunit genes. The encoded protein is a component of adaptor protein complex 1 (AP-1), one of the AP complexes involved in claathrin-mediated vesicular transport from the Golgi or endosomes. Disruption of the pathway for display of HIV-1 antigens, which prevents recognition of the virus by cytotoxic T cells, has been shown to involve the AP-1 complex (PMID: 15569716). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Description

AP1S3: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes small subunit family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Vesicle

Chromosomal Location of Human Ortholog: 2q36.1

Cellular Component: coated pit; cytoplasmic vesicle membrane; cytosol; Golgi membrane; lysosomal membrane; membrane coat; trans-Golgi network membrane

Molecular Function: protein binding; protein transporter activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; post-Golgi vesicle-mediated transport; protein targeting; regulation of defense response to virus by virus; viral reproduction

Disease: Psoriasis 15, Pustular, Susceptibility To