Activity
(Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.)
TRKC (G623R) Recombinant Protein | TRKC recombinant protein
TRKC (G623R), Active
Applications
Kinase Assay
Synonyms
TRKC (G623R); Active; NTRK3; gp145(trkC); TRKC recombinant protein
Host
Sf9 insect cells
Form/Format
Recombinant protein stored in 50mM sodium phosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, and 25% glycerol.
Applicable Applications for TRKC recombinant protein
Kinase Assay
Tag
HIS
Species
Human
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Activity
(Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.)
Activity
(Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.)
SDS-Page
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
SDS-Page
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
Related Product Information for TRKC recombinant protein
Recombinant human TRKC (G623R)(507-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. The gene accession number is NM_001012338.
TRKC is a member of the TRK family of tyrosine kinase receptors and is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). TRKC mediates the multiple cellular effects of the NT-3 neurotrophic factor, which includes neuronal differentiation and survival (1). TRKC has been implicated in insulin signaling pathway through interactions with the MUSK protein receptor and the VEGF receptor. Mutations in the TRKC gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers (2).
TRKC is a member of the TRK family of tyrosine kinase receptors and is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). TRKC mediates the multiple cellular effects of the NT-3 neurotrophic factor, which includes neuronal differentiation and survival (1). TRKC has been implicated in insulin signaling pathway through interactions with the MUSK protein receptor and the VEGF receptor. Mutations in the TRKC gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers (2).
Product Categories/Family for TRKC recombinant protein
References
1. Lamballe, F. et al: trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3". Cell, 1991; 66 (5): 967-79.
2. Marchetti, A. et al: Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. Hum Mutat. 2008 May;29(5):609-16.
2. Marchetti, A. et al: Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. Hum Mutat. 2008 May;29(5):609-16.
NCBI and Uniprot Product Information
Similar Products
Product Notes
The TRKC (Catalog #AAA517332) is a Recombinant Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TRKC (G623R) can be used in a range of immunoassay formats including, but not limited to, Kinase Assay. Researchers should empirically determine the suitability of the TRKC for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRKC (G623R), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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