Rabbit anti-Rat Anion Exchanger 3 Polyclonal Antibody | anti-Slc4a3 antibody

Anion Exchanger 3 (AE3, Anion exchange protein 3, BAE3, brain band 3-like protein, Neuronal band 3-like protein, SLC4A3, Solute carrier family 4 member 3)

Cat. Num. AAA611169

• Gene Names: Slc4a3; Ae3; Aep3
• Reactivity: Rat
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Anion Exchanger 3; Polyclonal Antibody; Anion Exchanger 3 (AE3; Anion exchange protein 3; BAE3; brain band 3-like protein; Neuronal band 3-like protein; SLC4A3; Solute carrier family 4 member 3); Anti -Anion Exchanger 3 (AE3; anti-Slc4a3 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes rat Anion Exchanger 3. No significant sequence homology is detected with other AE or other proteins. Does not recognize cardiac AE3. Epitope: ~N-terminal, cytoplasmic
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.1% BSA.

• Applicable Applications for anti-Slc4a3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 0.5-1ug/ml using the control peptide at 1ug/ml.; Western Blot (Chemiluminescence): 1-10ug/ml
• Immunogen: Synthetic peptide corresponding to aa13-32 from rat Anion Exchanger 3 conjugated to KLH. Species Sequence Homology: Mouse, 100%; human, 95%; rabbit, 90%.
• Preparation and Storage: -20 degree C

Related Product Information for anti-Slc4a3 antibody

Anion exchangers (AE) are membranes proteins involved in the regulation of intracellular pH, cell volume regulation as well as in transepithelial acid/base transport. AE proteins are sodium-independent exchangers that mediates one-for-one exchange of extracellular Cl- for intracellular HCO3- ions resulting in intracellular acidification. AE proteins are encoded by a family of at least three related genes (AE1, AE2, and AE3). Numerous alternatively spliced isoforms of each AE gene are expressed in various tissues. AE proteins are exemplified by a large N-terminal cytoplasmic domain (~40-75kD) that provides binding sites for cytoskeleton protein, glycolytic enzymes and hemoglobin. The N-terminal cytoplasmic domains of AE2 are AE3 are more closely related than AE1. In fact, AE1 N-terminus is 300 aa shorter than both the AE2 and AE3. The C-terminal TM domain (~55kD) is highly conserved (~70% identity) among various AE, spans the lipid bilayer 12-14 times, and is able to mediate anion exchange by itself.

Product Categories/Family for anti-Slc4a3 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 8394313
• NCBI GeneID: 24781
• NCBI Accession #: NP_058745.1
• NCBI GenBank Nucleotide #: NM_017049.1
• UniProt Accession #: P23348
• Molecular Weight: 135,407 Da
• NCBI Official Full Name: anion exchange protein 3
• NCBI Official Synonym Full Names: solute carrier family 4 (anion exchanger), member 3
• NCBI Official Symbol: Slc4a3
• NCBI Official Synonym Symbols: Ae3; Aep3
• NCBI Protein Information: anion exchange protein 3; AE 3; B3RP-3; anion exchanger 3; band 3-related protein 3; neuronal band 3-like protein; solute carrier family 4 member 3; Solute carrier family 4, member 3, anion exchange protein 3
• UniProt Protein Name: Anion exchange protein 3
• Protein Family: Anion exchange protein
• UniProt Gene Name: Slc4a3
• UniProt Synonym Gene Names: Ae3; B3rp3
• UniProt Entry Name: B3A3_RAT

NCBI Description

transmembrane anion transporter; functions as a chloride/bicarbonate exchanger; may be important for bicarbonate absorption in the heart [RGD]

Uniprot Description

SLC4A3: Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-). Belongs to the anion exchanger (TC 2.A.31) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: inorganic anion exchanger activity; anion:anion antiporter activity; anion transmembrane transporter activity

Biological Process: bicarbonate transport; regulation of intracellular pH; anion transport