Rabbit anti-Human AMACR Polyclonal Antibody | anti-AMACR antibody

Anti-AMACR Antibody

Cat. Num. AAA416297

• Gene Names: AMACR; RM; RACE; CBAS4; AMACRD
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: AMACR; Polyclonal Antibody; Anti-AMACR Antibody; anti-AMACR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 198

• Applicable Applications for anti-AMACR antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Optimal dilutions to be determined by researchers
• Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
• Immunogen: Recombinant protein
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Related Product Information for anti-AMACR antibody

This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]

NCBI and Uniprot Product Information

• NCBI GI #: 42822893
• NCBI GeneID: 23600
• NCBI Accession #: NP_976316.1
• NCBI GenBank Nucleotide #: NM_203382.2
• Molecular Weight: 43,860 Da
• NCBI Official Full Name: alpha-methylacyl-CoA racemase isoform 2
• NCBI Official Synonym Full Names: alpha-methylacyl-CoA racemase
• NCBI Official Symbol: AMACR
• NCBI Official Synonym Symbols: RM; RACE; CBAS4; AMACRD
• NCBI Protein Information: alpha-methylacyl-CoA racemase; 2-methylacyl-CoA racemase
• UniProt Protein Name: Alpha-methylacyl-CoA racemase
• Protein Family: Alpha-methylacyl-CoA racemase
• UniProt Gene Name: AMACR
• UniProt Entry Name: AMACR_HUMAN

NCBI Description

This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]

Uniprot Description

AMACR: Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. Belongs to the CaiB/BaiF CoA-transferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - primary bile acid biosynthesis; Isomerase; Mitochondrial; EC 5.1.99.4

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: peroxisomal matrix; mitochondrion; cytoplasm; peroxisome

Molecular Function: receptor binding; alpha-methylacyl-CoA racemase activity

Biological Process: bile acid biosynthetic process; fatty acid beta-oxidation using acyl-CoA oxidase; bile acid metabolic process; cellular lipid metabolic process

Disease: Bile Acid Synthesis Defect, Congenital, 4; Alpha-methylacyl-coa Racemase Deficiency