Rabbit anti-Human Amylin Polyclonal Antibody | anti-IAPP antibody

anti-Amylin antibody

Cat. Num. AAA766616

• Gene Names: IAPP; DAP; IAP
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Purification: Immunogen affinity purified; Purity: > = 95% as determined by SDS-PAGE
• Synonyms: Amylin; Polyclonal Antibody; anti-Amylin antibody; DAP; Diabetes associated peptide; IAP; IAPP; Insulinoma amyloid peptide; islet amyloid polypeptide; anti-IAPP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purification: Immunogen affinity purified; Purity: > = 95% as determined by SDS-PAGE
• Form/Format: Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

• Applicable Applications for anti-IAPP antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:20-1:200
• Immunogen: islet amyloid polypeptide
• Preparation and Storage: -20°C for 12 months. (Avoid repeated freeze / thaw cycles.).

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreas tissue slide using MBS766616 (Amylin Antibody) at dilution of 1:50 )

Related Product Information for anti-IAPP antibody

IAPP, also known as Amylin, is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. IAPP is co-secreted with insulin by pancreatic ?-cells and largely contributes to glycemic control. Studies suggest that this protein, like the related beta-amyloid(Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.

NCBI and Uniprot Product Information

• NCBI GI #: 457131
• NCBI GeneID: 3375
• UniProt Accession #: P10997; Q0ZD87; Q14598
• Molecular Weight: 10 kDa
• NCBI Official Full Name: amylin, partial
• NCBI Official Synonym Full Names: islet amyloid polypeptide
• NCBI Official Symbol: IAPP
• NCBI Official Synonym Symbols: DAP; IAP
• NCBI Protein Information: islet amyloid polypeptide
• UniProt Protein Name: Islet amyloid polypeptide
• Protein Family: Islet amyloid polypeptide
• UniProt Gene Name: IAPP
• UniProt Synonym Gene Names: DAP
• UniProt Entry Name: IAPP_HUMAN

NCBI Description

The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]

Uniprot Description

IAPP: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Belongs to the calcitonin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12p12.1

Cellular Component: cell soma; extracellular region; extracellular space

Molecular Function: hormone activity; identical protein binding; receptor binding

Biological Process: apoptosis; cell-cell signaling; cellular protein metabolic process; eating behavior; negative regulation of bone resorption; negative regulation of cell differentiation; sensory perception of pain; signal transduction