Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using ALS2CL Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200))
Rabbit anti-Human ALS2CL Polyclonal Antibody | anti-ALS2CL antibody
ALS2CL Antibody
Gene Names
ALS2CL; RN49018
Reactivity
Human
Applications
Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
ALS2CL; Polyclonal Antibody; ALS2CL Antibody; RN49018; anti-ALS2CL antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total ALS2CL protein.
Purity/Purification
Antigen affinity purification
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
0.3mg/ml (varies by lot)
Sequence Length
953
Applicable Applications for anti-ALS2CL antibody
Immunohistochemistry (IHC)
Application Notes
Immunohistochemistry: 1: 20-100
Immunogen
Synthetic peptide of human ALS2CL
Immunogen Type
Peptide
Preparation and Storage
Store at -20 degree C
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using ALS2CL Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using ALS2CL Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using ALS2CL Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using ALS2CL Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200))
Related Product Information for anti-ALS2CL antibody
Mutations in the ALS2 gene result in a number of juvenile recessive motor neuron diseases (MNDs), including juvenile primary lateral sclerosis (JPLS), a recessive form of amyotrophic lateral sclerosis (ALS2), infantile onset ascending hereditary spastic paralysis (IAHSP) and a form of complicated hereditary spastic paraplegia (cHSP). The ALS2 gene encodes the Alsin protein. Alsin acts as a guanine nucleotide exchange factor for Rab5, a modulator of the endocytic pathway. Alsin is a cytosolic protein, which is associated with small, punctate membrane structures. Therefore Alsin may mediate membrane transport events, potentially linking endocytic processes and actin cytoskeleton remodeling. The ALS2 C-terminal like protein (ALS2CL) also modulates Rab5 activity.
Product Categories/Family for anti-ALS2CL antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
34,998 Da
NCBI Official Full Name
ALS2 C-terminal-like protein isoform 1
NCBI Official Synonym Full Names
ALS2 C-terminal like
NCBI Official Symbol
ALS2CL
NCBI Official Synonym Symbols
RN49018
NCBI Protein Information
ALS2 C-terminal-like protein
UniProt Protein Name
ALS2 C-terminal-like protein
Protein Family
UniProt Gene Name
ALS2CL
UniProt Entry Name
AL2CL_HUMAN
Uniprot Description
ALS2CL: Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs; GEFs, Rab
Chromosomal Location of Human Ortholog: 3p21.31
Molecular Function: identical protein binding
Biological Process: endosome organization and biogenesis
Research Articles on ALS2CL
Similar Products
Product Notes
The ALS2CL als2cl (Catalog #AAA9417116) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ALS2CL Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ALS2CL can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1: 20-100. Researchers should empirically determine the suitability of the ALS2CL als2cl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ALS2CL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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