Rabbit alpha-tubulin Polyclonal Antibody | anti-TUBA4A antibody

alpha-tubulin Rabbit pAb

Cat. Num. AAA8808230

• Gene Names: TUBA4A; TUBA1; H2-ALPHA
• Reactivity: Human, Rat, Mouse
• Synonyms: alpha-tubulin; Polyclonal Antibody; alpha-tubulin Rabbit pAb; anti-TUBA4A antibody

• Host: Rabbit
• Reactivity: Human, Rat, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: PBS with 0.02% sodium azide and 50% glycerol pH7.4.
• Concentration: 1mg/ml (varies by lot)

• Species: Human
• Immunogen: Recombinant Protein
• Preparation and Storage: Store at -20 degree C. Avoid repeated freeze-thaw cycles.

Western Blot (WB)

(Western blot analysis of 1) Mouse skeletal muscle tissue, 2) Mouse kidney tissue, 3) Mouse Heart Tissue, 4) Mouse brain tissue, 5) Mouse Liver tissue with alpha-tubulin Rabbit pAb diluted at 1:2,000. )

Western Blot (WB)

(Western blot analysis of 1) Rat Brain tissue, 2) Rat Liver tissue, 3) Rat Heart Tissue, 4) HepG2, 5) 293T,with alpha-tubulin Rabbit pAb diluted at 1:2,000. )

Western Blot (WB)

(Western blot analysis of extracts from HeLa (Lane 1),MCF-7 (Lane 2), 3T3 (Lane 3), Rat Kidney (Lane 4), using alpha-Tubulin diluted at 1:3,000.)

Related Product Information for anti-TUBA4A antibody

Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are alpha-tubulin and beta-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of alpha- and beta-tubulin. 

NCBI and Uniprot Product Information

• NCBI GI #: 55977476
• NCBI GeneID: 7277
• UniProt Accession #: P68366; P05215; A8MUB1; B3KNQ6
• Molecular Weight: 448
• NCBI Official Full Name: Tubulin alpha-4A chain
• NCBI Official Synonym Full Names: tubulin, alpha 4a
• NCBI Official Symbol: TUBA4A
• NCBI Official Synonym Symbols: TUBA1; H2-ALPHA
• NCBI Protein Information: tubulin alpha-4A chain; tubulin H2-alpha; tubulin alpha-1 chain; tubulin, alpha 1 (testis specific)
• UniProt Protein Name: Tubulin alpha-4A chain
• Protein Family: Alpha-tubulin N-acetyltransferase
• UniProt Gene Name: TUBA4A
• UniProt Synonym Gene Names: TUBA1
• UniProt Entry Name: TBA4A_HUMAN

NCBI Description

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

Uniprot Description

TUBA4A: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Belongs to the tubulin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: microtubule; extracellular region; cytosol

Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton

Biological Process: protein polymerization; 'de novo' posttranslational protein folding; platelet activation; cellular protein metabolic process; platelet degranulation; protein folding; organelle organization and biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; blood coagulation; microtubule-based process

Disease: Amyotrophic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia