Goat anti-Human Alpha Fetoprotein Polyclonal Antibody | anti-AFP antibody
Affinity Purified Goat anti-Human Alpha Fetoprotein
Shelf Life: 12 months after shipping date
NCBI and Uniprot Product Information
NCBI Description
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq]
Uniprot Description
AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component: extracellular space; cytoplasm
Molecular Function: metal ion binding
Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle
Disease: Alpha-fetoprotein Deficiency; Alpha-fetoprotein, Hereditary Persistence Of
Research Articles on AFP
2. The simultaneous determination of serum AFP, ferritin and IGF-1 may help in differential diagnosis of liver diseases.
3. Genetic variants in the AFP gene may be associated with HCC and cirrhosis risk for ethnic Indonesians.
4. Elevated maternal serum AFP (alpha-fetoprotein) levels were detected in second trimester in women at risk for placental insufficiency
5. Studies show that AFP enhancer can specifically enhance the expression of target TK gene within the AFP positive cell, and induce bystander effect and apoptosis in the AFP positive HepG2 cell with with GCV.
6. Multivariate analysis showed progression of AFP>15 microg/L per month and preoperative nodules>3 were associated with decreased overall survival in liver transplantation for hepatocellular carcinoma in cirrhotic patients.
7. SALL4 is a more sensitive marker than PLAP, AFP, or glypican-3 for extragonadal yolk sac tumors.
8. AFP may modulate inflammatory events in human skin.
9. Alpha-fetoprotein mRNA levels in peripheral blood of patients with hepatocellular carcinoma
10. Serum AFP level at end of interferon therapy is a possible predictor of hepatocellular carcinoma in chronic hepatitis C patients after interferon therapy.
11. All-trans-retinoic-acid resistance of hepatoma Bel 7402 cells is at least in part attributable to their high level of cytoplasmic alpha-fetoprotein.
12. Serum AFP levels ranging between 200-800 ng/ml were associated with high expression of somatostatin receptors in hepatocellular carcinoma.
13. Maternal serum alpha-fetoprotein levels are strongly related to preterm birth, but only in the context of other abnormal pregnancy markers.
14. Report novel alpha-fetoprotein-V messenger RNA isoforms in humans.
15. Serum PIVKA-II level, not serum AFP, was a valuable independent prognostic factor in HBV-related hepatocellular carcinoma.
16. Assessment of Dkk3 and AFP may be useful in the diagnosis of hepatic tumors.
17. AFP promoter enhancer increased specific expression of the human sodium iodide symporter (hNIS) for targeted radioiodine therapy of hepatocellular carcinoma.
18. Alpha-fetoprotein was more sensitive than des-gamma carboxyprothrombin and lectin-bound alpha-fetoprotein in diagnosing early hepatocellular carcinoma.
19. Case Report: Alpha-fetoprotein (AFP)-producing ovarian tumor in an elderly woman.
20. The utility of the tumour markers carcinoembryonic antigen, cancer antigen 125, carbohydrate antigen 19-9, carbohydrate antigen 15-3, alpha-fetoprotein and human chorionic gonadotropin for the diagnosis solitary pulmonary nodules, was investigated.
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Product Notes
The AFP afp (Catalog #AAA560255) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Affinity Purified Goat anti-Human Alpha Fetoprotein reacts with Human and may cross-react with other species as described in the data sheet. This product has been qualified by ELISA, immunoelectrophoresis and gel diffusion techniques. Researchers should empirically determine the suitability of the AFP afp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Alpha Fetoprotein, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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