Western Blot (WB)
(ALG11 Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the ALG11 antibody detected the ALG11 protein (arrow).)
Rabbit anti-Human, mouse ALG11 Polyclonal Antibody | anti-ALG11 antibody
ALG11 Antibody (C-term)
Western Blot (WB)
(ALG11 Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the ALG11 antibody detected the ALG11 protein (arrow).)
Western Blot (WB)
(ALG11 Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the ALG11 antibody detected the ALG11 protein (arrow).)
GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which
is localized to the cytosolic side of the endoplasmic reticulum
(ER) and catalyzes the transfer of the fourth and fifth mannose
residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and
Man4GlcNAc2-PP-dolichol resulting in the production of
Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with
congenital disorder of glycosylation type Ip (CDGIP). This gene
overlaps but is distinct from the UTP14, U3 small nucleolar
ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the
GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has
been identified on chromosome 19.
Rohozinski, J., et al. Biol. Reprod. 74(4):644-651(2006)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010]
Uniprot Description
ALG11: Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol- linked oligosaccharide chain. Defects in ALG11 are the cause of congenital disorder of glycosylation type 1P (CDG1P). A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Protein type: Glycan Metabolism - N-glycan biosynthesis; Transferase; EC 2.4.1.131; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q14.2
Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane
Molecular Function: glycolipid 2-alpha-mannosyltransferase activity
Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Disease: Congenital Disorder Of Glycosylation, Type Ip
Research Articles on ALG11
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Product Notes
The ALG11 alg11 (Catalog #AAA9211219) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 442-468. The ALG11 Antibody (C-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ALG11 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the ALG11 alg11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ALG11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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