Western Blot (WB)
(Western Blot analysis of ALDOB expression in transfected 293T cell line by ALDOB polyclonal antibody. Lane 1: ALDOB transfected lysate (39.5kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human ALDOB Polyclonal Antibody | anti-ALDOB antibody
ALDOB (Fructose-bisphosphate Aldolase B, Liver-type Aldolase, ALDB) (Biotin)
Western Blot (WB)
(Western Blot analysis of ALDOB expression in transfected 293T cell line by ALDOB polyclonal antibody. Lane 1: ALDOB transfected lysate (39.5kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of ALDOB expression in transfected 293T cell line by ALDOB polyclonal antibody. Lane 1: ALDOB transfected lysate (39.5kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]
Uniprot Description
ALDOB: Defects in ALDOB are the cause of hereditary fructose intolerance (HFI). HFI is an autosomal recessive disease that results in an inability to metabolize fructose and related sugars. Complete exclusion of fructose results in dramatic recovery; however, if not treated properly, HFI subjects suffer episodes of hypoglycemia, general ill condition, and risk of death the remainder of life. Belongs to the class I fructose-bisphosphate aldolase family.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - fructose and mannose; EC 4.1.2.13; Lyase; Carbohydrate Metabolism - pentose phosphate pathway
Chromosomal Location of Human Ortholog: 9q21.3-q22.2
Cellular Component: microtubule organizing center; cytosol
Molecular Function: identical protein binding; protein binding; cytoskeletal protein binding; fructose-bisphosphate aldolase activity; ATPase binding
Biological Process: fructose 1,6-bisphosphate metabolic process; NADH oxidation; glycolysis; positive regulation of ATPase activity; carbohydrate metabolic process; glucose metabolic process; pathogenesis; fructose catabolic process; gluconeogenesis; fructose metabolic process
Disease: Fructose Intolerance, Hereditary
Research Articles on ALDOB
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Product Notes
The ALDOB aldob (Catalog #AAA6369563) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ALDOB (Fructose-bisphosphate Aldolase B, Liver-type Aldolase, ALDB) (Biotin) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ALDOB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the ALDOB aldob for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ALDOB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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