Rabbit anti-Human ALDH6A1 Polyclonal Antibody | anti-ALDH6A1 antibody

ALDH6A1 (MMSDH, Methylmalonate-semialdehyde Dehydrogenase [Acylating], Mitochondrial, Aldehyde Dehydrogenase Family 6 Member A1, MGC40271) (HRP)

Cat. Num. AAA6369521

• Gene Names: ALDH6A1; MMSDH; MMSADHA
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ALDH6A1; Polyclonal Antibody; ALDH6A1 (MMSDH; Methylmalonate-semialdehyde Dehydrogenase [Acylating]; Mitochondrial; Aldehyde Dehydrogenase Family 6 Member A1; MGC40271) (HRP); anti-ALDH6A1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human ALDH6A1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-ALDH6A1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human ALDH6A1, aa1-535 (NP_005580.1).
• Immunogen Sequence: MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of ALDH6A1 expression in transfected 293T cell line by ALDH6A1 polyclonal antibody. Lane 1: ALDH6A1 transfected lysate (57.8kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-ALDH6A1 antibody

ALDH6A1 belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. This protein is a mitochondrial methylmalonate semialdehyde dehydrogenase, and catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl-and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids.

Product Categories/Family for anti-ALDH6A1 antibody

Antibodies; Enzymes; Dehydrogenase

NCBI and Uniprot Product Information

• NCBI GI #: 11095441
• NCBI GeneID: 4329
• NCBI Accession #: NP_005580.1
• NCBI GenBank Nucleotide #: NM_005589.2
• UniProt Accession #: Q02252; Q9UKM8; B2R609; B4DFS8; J3KNU8
• Molecular Weight: 56,228 Da
• NCBI Official Full Name: methylmalonate-semialdehyde dehydrogenase
• NCBI Official Synonym Full Names: aldehyde dehydrogenase 6 family, member A1
• NCBI Official Symbol: ALDH6A1
• NCBI Official Synonym Symbols: MMSDH; MMSADHA
• NCBI Protein Information: methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; mitochondrial acylating methylmalonate-semialdehyde dehydrogenase
• UniProt Protein Name: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
• UniProt Gene Name: ALDH6A1
• UniProt Synonym Gene Names: MMSDH; MMSDH; Malonate-semialdehyde dehydrogenase [acylating]
• UniProt Entry Name: MMSA_HUMAN

NCBI Description

This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Uniprot Description

ALDH6A1: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. Defects in ALDH6A1 are the cause of methylmalonate semialdehyde dehydrogenase deficiency (MMSDHD). This is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Belongs to the aldehyde dehydrogenase family.

Protein type: Carbohydrate Metabolism - inositol phosphate; EC 1.2.1.27; EC 1.2.1.18; Mitochondrial; Oxidoreductase; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix

Molecular Function: aldehyde dehydrogenase (NAD) activity; acyl-CoA binding; methylmalonate-semialdehyde dehydrogenase (acylating) activity; malonate-semialdehyde dehydrogenase (acetylating) activity

Biological Process: valine catabolic process; thymine metabolic process; brown fat cell differentiation; thymine catabolic process; valine metabolic process; branched chain family amino acid catabolic process

Disease: Methylmalonate Semialdehyde Dehydrogenase Deficiency