Rabbit anti-Human, Mouse Aldh3A2 Polyclonal Antibody | anti-ALDH3A2 antibody

Aldh3A2 Antibody

Cat. Num. AAA150209

• Gene Names: ALDH3A2; SLS; FALDH; ALDH10
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Aldh3A2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: Aldh3A2; Polyclonal Antibody; Aldh3A2 Antibody; SLS; FALDH; ALDH10; Fatty aldehyde dehydrogenase; Aldehyde dehydrogenase 10; aldehyde dehydrogenase 3 family; member A2; anti-ALDH3A2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least four isoforms of Aldh3A2 are known to exist. This antibody is predicted to have no cross-reactivity to Aldh3A1.
• Purity/Purification: Aldh3A2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 508

• Applicable Applications for anti-ALDH3A2 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Aldh3A2 antibody can be used for detection of Aldh3A2 by Western blot at 1 - 2 mug/mL.
• Conjugate: Unconjugated
• Immunogen: Aldh3A2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human Aldh3A2.
• Buffer: Aldh3A2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Aldh3A2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of Aldh3A2 in mouse liver lysate with Aldh3A2 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-ALDH3A2 antibody

Aldh3A2 Antibody: Aldh3A2 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh3A2 catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Mutations in the Aldh3A2 gene cause Sjogren-Larrson syndrome, an inherited neurocutaneous disorder. Patients with this disorder display ichthyosis, mental retardation and spastic diplegia. The pathogenesis of the cutaneous and neurological symptoms is thought to result from abnormal lipid accumulation in the membranes of skin and brain, the formation of aldehyde Schiff base adducts with amine-containing lipids or proteins, or defective eicosanoid metabolism.

NCBI and Uniprot Product Information

• NCBI GI #: 73466520
• NCBI GeneID: 224
• NCBI Accession #: NP_001026976
• NCBI GenBank Nucleotide #: NM_001031806.1
• UniProt Accession #: P51648; Q6I9T3; Q93011; Q96J37
• Molecular Weight: 57,669 Da
• NCBI Official Full Name: fatty aldehyde dehydrogenase isoform 1
• NCBI Official Synonym Full Names: aldehyde dehydrogenase 3 family, member A2
• NCBI Official Symbol: ALDH3A2
• NCBI Official Synonym Symbols: SLS; FALDH; ALDH10
• NCBI Protein Information: fatty aldehyde dehydrogenase; aldehyde dehydrogenase 10; microsomal aldehyde dehydrogenase; aldehyde dehydrogenase family 3 member A2
• UniProt Protein Name: Fatty aldehyde dehydrogenase
• Protein Family: Fatty aldehyde dehydrogenase
• UniProt Gene Name: ALDH3A2
• UniProt Synonym Gene Names: ALDH10; FALDH
• UniProt Entry Name: AL3A2_HUMAN

NCBI Description

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ALDH3A2: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. Defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS). SLS is an autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis (increased keratinization). Ichthyosis is usually evident at birth, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Membrane protein, integral; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - arginine and proline; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Amino Acid Metabolism - tryptophan; Secondary Metabolites Metabolism - limonene and pinene degradation; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - histidine; Lipid Metabolism - glycerolipid; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - ascorbate and aldarate; Oxidoreductase; Amino Acid Metabolism - lysine degradation

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; mitochondrial inner membrane; integral to membrane; peroxisome

Molecular Function: long-chain-alcohol oxidase activity; aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; 3-chloroallyl aldehyde dehydrogenase activity; long-chain-aldehyde dehydrogenase activity

Biological Process: phytol metabolic process; epidermis development; central nervous system development; aldehyde metabolic process; sesquiterpenoid metabolic process; peripheral nervous system development

Disease: Sjogren-larsson Syndrome