Rabbit anti-Human Akt2, gamma Polyclonal Antibody | anti-Akt2 antibody
Akt2, gamma (PKBb, RAC-PK Gamma 2)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: Western Blot (HEK293 cell lysate): 1:4000- 1:16,000 (60kD) 1ug AKT2 using TMB Stable Liquid Substrate for HRPO (3,3',5,5'-Tetramethylbenzidine) T6000 or T6005 as a substrate for 30 minutes at RT.
NCBI and Uniprot Product Information
Uniprot Description
Akt2: an AGC kinase. Plays critical roles in glucose metabolism and the development or maintenance of proper adipose tissue and islet mass for which other Akt/PKB isoforms are unable to fully compensate. Amplified and overexpressed in human ovarian carcinoma cell lines and amplified in some primary ovarian and pancreatic tumors. Antisense blocks invasiveness in xenografts. Expressed in several insulin-responsive tissues, and one case of Type II diabetes has been associated with a likely LOF point mutation. Mouse mutants have defects in insulin response.
Protein type: EC 2.7.11.1; Oncoprotein; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; AKT family
Cellular Component: membrane; intracellular membrane-bound organelle; cytoplasm; plasma membrane; cell cortex; cytosol; nucleus; vesicle
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; protein kinase C binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity
Biological Process: glycogen metabolic process; positive regulation of positive chemotaxis; positive regulation of nitric oxide biosynthetic process; apoptosis; multicellular organismal development; positive regulation of glycogen biosynthetic process; intracellular protein transport across a membrane; positive regulation of vesicle fusion; negative regulation of caspase activity; protein amino acid phosphorylation; regulation of translation; positive regulation of glucose import; negative regulation of RNA splicing; transport; protein kinase B signaling cascade; glycogen biosynthetic process; positive regulation of signal transduction; carbohydrate transport; myelin maintenance in the peripheral nervous system; glucose metabolic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of fatty acid beta-oxidation; cellular response to insulin stimulus; carbohydrate metabolic process; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; phosphorylation; negative regulation of apoptosis; positive regulation of cell migration
Research Articles on Akt2
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Product Notes
The Akt2 akt2 (Catalog #AAA615730) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Akt2, gamma (PKBb, RAC-PK Gamma 2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Akt2, gamma can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: Western Blot (HEK293 cell lysate): 1:4000- 1:16,000 (60kD) 1ug AKT2 using TMB Stable Liquid Substrate for HRPO (3,3',5,5'-Tetramethylbenzidine) T6000 or T6005 as a substrate for 30 minutes at RT. Researchers should empirically determine the suitability of the Akt2 akt2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Akt2, gamma, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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