Western Blot (WB)
(AKAP5 Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the AKAP5 antibody detected the AKAP5 protein (arrow).)
Rabbit anti-Human AKAP5 Polyclonal Antibody | anti-AKAP5 antibody
AKAP5 Antibody (Center)
Western Blot (WB)
(AKAP5 Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the AKAP5 antibody detected the AKAP5 protein (arrow).)
Western Blot (WB)
(AKAP5 Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the AKAP5 antibody detected the AKAP5 protein (arrow).)
structurally diverse proteins, which have the common function of
binding to the regulatory subunit of protein kinase A (PKA) and
confining the holoenzyme to discrete locations within the cell.
This gene encodes a member of the AKAP family. The encoded protein
binds to the RII-beta regulatory subunit of PKA, and also to
protein kinase C and the phosphatase calcineurin. It is
predominantly expressed in cerebral cortex and may anchor the PKA
protein at postsynaptic densities (PSD) and be involved in the
regulation of postsynaptic events. It is also expressed in T
lymphocytes and may function to inhibit interleukin-2 transcription
by disrupting calcineurin-dependent dephosphorylation of NFAT.
Chen, M.H., et al. Cell. Signal. 21(1):136-142(2009)
Tavalin, S.J. J. Biol. Chem. 283(17):11445-11452(2008)
Correia, S.S., et al. Nat. Neurosci. 11(4):457-466(2008)
Chai, S., et al. J. Biol. Chem. 282(31):22668-22677(2007)
NCBI and Uniprot Product Information
NCBI Description
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]
Uniprot Description
AKAP5: May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C. Interacts with ADCY8, and enhances its phosphorylation at lipid rafts. Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 14q23.3
Cellular Component: plasma membrane; cytosol
Molecular Function: calmodulin binding; protein binding; protein kinase A binding; adenylate cyclase binding
Biological Process: synaptic transmission; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; signal transduction; regulation of insulin secretion; protein targeting
Research Articles on AKAP5
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Product Notes
The AKAP5 akap5 (Catalog #AAA9209261) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 115-143. The AKAP5 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's AKAP5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the AKAP5 akap5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AKAP5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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