Rabbit anti-Human AK4 / Adenylate Kinase 4 Polyclonal Antibody | anti-AK4 antibody

Anti-AK4 / Adenylate Kinase 4 Antibody (aa1-209) IHC-plus

Cat. Num. AAA2400407

• Gene Names: AK4; AK3; AK 4; AK3L1; AK3L2
• Reactivity: Human
• Applications: Immunohistochemistry, Immunocytochemistry, Western Blot
• Purity: Immunoaffinity purified
• Synonyms: AK4 / Adenylate Kinase 4; Polyclonal Antibody; Anti-AK4 / Adenylate Kinase 4 Antibody (aa1-209) IHC-plus; Rabbit Polyclonal to Human AK4 / Adenylate Kinase 4; Human AK4 / Adenylate Kinase 4; Adenylate kinase 3-like 1; Adenylate kinase 4; Adenylate kinase 3-like; Adenylate kinase 3; AK3L1; ATP-AMP transphosphorylase; AK3L2; GTP:AMP phosphotransferase; anti-AK4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human AK4 / Adenylate Kinase 4
• Purity/Purification: Immunoaffinity purified
• Form/Format: 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 223

• Applicable Applications for anti-AK4 antibody: Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC), Western Blot (WB)
• Application Notes: ICC (1:100 - 1:1000); IHC-P (10 ug/ml); WB (1:500 - 1:3000)
• Immunogen: AK4 / Adenylate Kinase 4 antibody was raised against recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 209 (P27144) of Adenylate kinase 3. Percent identity by BLAST analysis: Human (100%); Bovine (92%); Mouse (89%).
• Immunogen Description: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 209 (P27144) of Adenylate kinase 3. Percent identity by BLAST analysis: Human (100%); Bovine (92%); Mouse (89%).
• Immunogen Type: Recombinant protein
• Antigen Modification: aa1-209
• Target Species: Human
• Preparation and Storage: Keep as concentrated solution. Aliquot and store at -20 degree C or below. Avoid multiple freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-AK4 / Adenylate Kinase 4 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunocytochemistry (ICC)

(Immunofluorescence of methanol-fixed HeLa using Adenylate kinase 3 antibody at 1:100 dilution.)

Western Blot (WB)

(Sample (30 ug whole cell lysate). A:293T, B: A431, C: H1299, D: HeLa S3, E: Hep G2. F: Raji. 12% SDS PAGE. AK4 / Adenylate Kinase 4 antibody diluted at 1:1000)

Related Product Information for anti-AK4 antibody

AK4 Antibody, Adenylate kinase 3-like 1 Antibody, Adenylate kinase 4 Antibody, Adenylate kinase 3-like Antibody, Adenylate kinase 3 Antibody, AK3L1 Antibody, ATP-AMP transphosphorylase Antibody, AK3L2 Antibody, GTP:AMP phosphotransferase Antibody Description: AK4 / Adenylate Kinase 4 is a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated.

NCBI and Uniprot Product Information

• NCBI GI #: 8051579
• NCBI GeneID: 205
• NCBI Accession #: NP_037542.1
• NCBI GenBank Nucleotide #: NM_013410.3
• UniProt Accession #: P27144; Q6IBH4; Q6NXQ5; Q8IUU9; B2R927; D3DQ62
• Molecular Weight: 25,268 Da
• NCBI Official Full Name: adenylate kinase 4, mitochondrial
• NCBI Official Synonym Full Names: adenylate kinase 4
• NCBI Official Symbol: AK4
• NCBI Official Synonym Symbols: AK3; AK 4; AK3L1; AK3L2
• NCBI Protein Information: adenylate kinase 4, mitochondrial
• UniProt Protein Name: Adenylate kinase 4, mitochondrial
• UniProt Gene Name: AK4
• UniProt Synonym Gene Names: AK 4
• UniProt Entry Name: KAD4_HUMAN

NCBI Description

This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Description

AK3L1: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. May also be active with GTP. Belongs to the adenylate kinase family.

Protein type: Nucleotide Metabolism - purine; Mitochondrial; Kinase, other; EC 2.7.4.10; EC 2.7.4.6

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: adenylate kinase activity; ATP binding; GTP binding; nucleoside diphosphate kinase activity; nucleoside triphosphate adenylate kinase activity

Biological Process: ADP biosynthetic process; AMP metabolic process; ATP metabolic process; brain development; GTP metabolic process; liver development; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process; response to drug