AID Polyclonal Antibody | anti-AID antibody

AID Polyclonal Antibody

Gene Names

AICDA; AID; ARP2; CDA2; HIGM2; HEL-S-284

Synonyms

AID; Polyclonal Antibody; AID Polyclonal Antibody; anti-AID antibody

Ordering
Cat. Num. AAA8526547 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Clonality

Polyclonal

Sequence Length

188

NCBI and Uniprot Product Information

NCBI GI #

1057867551

NCBI GeneID

57379

NCBI Accession #

NP_001317272.1

NCBI GenBank Nucleotide #

NM_001330343.1

UniProt Accession #

Q9GZX7; Q6QJ81; Q8NFC1

Molecular Weight

22,614 Da

NCBI Official Full Name

single-stranded DNA cytosine deaminase isoform 2

NCBI Official Synonym Full Names

activation induced cytidine deaminase

NCBI Official Symbol

AICDA

NCBI Official Synonym Symbols

AID; ARP2; CDA2; HIGM2; HEL-S-284

NCBI Protein Information

single-stranded DNA cytosine deaminase

UniProt Protein Name

Single-stranded DNA cytosine deaminase

Protein Family

AIDA-I autotransporter

UniProt Gene Name

AICDA

UniProt Synonym Gene Names

AID; AID

NCBI Description

This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]

Uniprot Description

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).

Research Articles on AID

1. we reported high AID, low miR-181b and high miR-155 expression in de novo adult B-ALL patients. Univariate high AID or low miR-181b expression was an unfavorable prognostic factor. High AID with low miR-181b or with low miR-155 expression is better in predicting unfavorable OS than univariate factor. High AID with low miR-181b and low miR-155 expression confers worst prognosis.

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Product Notes

The AID aicda (Catalog #AAA8526547) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AID, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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AID Polyclonal Antibody | anti-AID antibody