Rabbit anti-Human AGTRAP Polyclonal Antibody | anti-AGTRAP antibody

AGTRAP Antibody

Cat. Num. AAA7050477

• Gene Names: AGTRAP; ATRAP
• Reactivity: Human
• Applications: ELISA, Immunofluorescence
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Synonyms: AGTRAP; Polyclonal Antibody; AGTRAP Antibody; Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein; ATRAP; anti-AGTRAP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
• Form/Format: Liquid
• Sequence Length: 152

• Applicable Applications for anti-AGTRAP antibody: ELISA (EIA), Immunofluorescence (IF)
• Immunogen: Recombinant human Type-1 angiotensin II receptor-associated protein (108-152AA)
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugation: Non-conjugated
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunofluorescence (IF)

(Immunofluorescent analysis of 293 cells using MBS7050477 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-AGTRAP antibody

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project TeamGenome Res. 14: 2121-2127(2004). [2]"The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling." Lopez-Ilasaca M., Liu X., Tamura K., Dzau V.J.Mol. Biol. Cell 14: 5038-5050(2003). [3]"Initial characterization of the human central proteome."Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5: 17-17(2011).

NCBI and Uniprot Product Information

• NCBI GI #: 93588491
• NCBI GeneID: 57085
• NCBI Accession #: NP_001035284.1
• NCBI GenBank Nucleotide #: NM_001040194.1
• UniProt Accession #: Q6RW13; Q5SNV4; Q5SNV5; Q96AC0; Q96PL4; Q9NRW9; A8MVQ5
• Molecular Weight: 11,948 Da
• NCBI Official Full Name: type-1 angiotensin II receptor-associated protein isoform b
• NCBI Official Synonym Full Names: angiotensin II receptor associated protein
• NCBI Official Symbol: AGTRAP
• NCBI Official Synonym Symbols: ATRAP
• NCBI Protein Information: type-1 angiotensin II receptor-associated protein
• UniProt Protein Name: Type-1 angiotensin II receptor-associated protein
• Protein Family: Type-1 angiotensin II receptor-associated protein
• UniProt Gene Name: AGTRAP
• UniProt Synonym Gene Names: ATRAP
• UniProt Entry Name: ATRAP_HUMAN

NCBI Description

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

AGTRAP: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleoplasm

Molecular Function: protein binding