Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/15.)
Rabbit anti-Human AGTR2 Polyclonal Antibody | anti-AGTR2 antibody
AGTR2 Antibody
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/15.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/15.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/15.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/15.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. [provided by RefSeq, Jan 2010]
Uniprot Description
AT2: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. Defects in AGTR2 are the cause of mental retardation X- linked type 88 (MRX88). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1
Chromosomal Location of Human Ortholog: Xq22-q23
Cellular Component: perinuclear region of cytoplasm; integral to plasma membrane; extracellular region; plasma membrane
Molecular Function: receptor antagonist activity; protein binding; angiotensin type II receptor activity; peptide hormone binding; transcription factor binding
Biological Process: positive regulation of phosphoprotein phosphatase activity; negative regulation of icosanoid secretion; regulation of transcription factor import into nucleus; negative regulation of heart rate; positive regulation of nitric oxide biosynthetic process; negative regulation of nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; renin-angiotensin regulation of aldosterone production; dopamine biosynthetic process; positive regulation of vasodilation; angiotensin mediated vasodilation involved in regulation of systemic arterial blood pressure; cerebellar cortex development; regulation of systemic arterial blood pressure by circulatory renin-angiotensin; cell surface receptor linked signal transduction; regulation of blood pressure; positive regulation of cell proliferation; inflammatory response; cellular sodium ion homeostasis; positive regulation of nitric-oxide synthase activity; response to organic nitrogen; negative regulation of blood vessel endothelial cell migration; brain renin-angiotensin system; G-protein coupled receptor protein signaling pathway; negative regulation of fibroblast proliferation; blood vessel remodeling; G-protein signaling, coupled to cGMP nucleotide second messenger; brain development; negative regulation of cell growth; nitric oxide mediated signal transduction; positive regulation of cytokine secretion
Research Articles on AGTR2
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Product Notes
The AGTR2 agtr2 (Catalog #AAA9406360) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AGTR2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's AGTR2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:25-1:100. Researchers should empirically determine the suitability of the AGTR2 agtr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AGTR2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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