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Western Blot (WB) (Western Blot (WB) analysis of AGP-2 polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:sp2/0 whole cell lysateLane3:H9C2 whole cell lysate)

Rabbit AGP-2 Polyclonal Antibody | anti-AGP-2 antibody

AGP-2 Polyclonal Antibody

Gene Names
ORM2; AGP2; AGP-B; AGP-B'
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
AGP-2; Polyclonal Antibody; AGP-2 Polyclonal Antibody; Alpha-1-acid glycoprotein 2; AGP 2; Orosomucoid-2; Orosomucoid 2; Orosomucoid2; OMD 2; OMD2; ORM2; ORM-2; AGP2; anti-AGP-2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
AGP-2 polyclonal antibody detects endogenous levels of AGP-2 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
201
Applicable Applications for anti-AGP-2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500-1:1000
IHC: 1:50-1:200
Immunogen
A synthetic peptide corresponding to residues in Human AGP-2.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of AGP-2 polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:sp2/0 whole cell lysateLane3:H9C2 whole cell lysate)

Western Blot (WB) (Western Blot (WB) analysis of AGP-2 polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:sp2/0 whole cell lysateLane3:H9C2 whole cell lysate)

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of AGP-2 pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50,showing secreted and membrane staining. Negative control (the right) Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.)

Immunohistochemistry (IHC) (Immunohistochemistry (IHC) analyzes of AGP-2 pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50,showing secreted and membrane staining. Negative control (the right) Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.)

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of AGP-2 pAb in paraffin-embedded human liver carcinoma tissue at 1:50,showing secreted and membrane staining. Negative control (the right) Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase)

Immunohistochemistry (IHC) (Immunohistochemistry (IHC) analyzes of AGP-2 pAb in paraffin-embedded human liver carcinoma tissue at 1:50,showing secreted and membrane staining. Negative control (the right) Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase)
Related Product Information for anti-AGP-2 antibody
AGP (a 1-acid Glycoprotein) is an acute phase plasma protein synthesized by the liver. It functions to regulate the interaction between blood cells and endothelial cells, and together with haptoglobin and C reactive protein, it also mediates the extravasation of cells during infection and inflammation. Expression of AGP is induced by acute-phase stimulatory agents such as bacterial lipopolysaccharides. AGP has a high affinity, low capacity binding for basic drugs at physiological pH. In human plasma, AGP is found at levels of 0.5-1.4 mg/ml, though this is elevated during acute inflammation, and, as a result, levels of this protein can be used to identify inflammatory conditions. Multiple AGP genes exist, including AGP-1, AGP-2, AGP-3 and AGP-8. AGP-1 and AGP-2 contain five and six potential N-glycosylation sites, respectively. Abnormal expression of the APG-1 gene is linked to sarcoidosis and other immunogenetic diseases, while mutations in the APG-2 gene are associated with different types of carcinomas.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
~ 24, 45kDa
NCBI Official Full Name
orosomucoid 2
NCBI Official Synonym Full Names
orosomucoid 2
NCBI Official Symbol
ORM2
NCBI Official Synonym Symbols
AGP2; AGP-B; AGP-B'
NCBI Protein Information
alpha-1-acid glycoprotein 2
UniProt Protein Name
Alpha-1-acid glycoprotein 2
UniProt Gene Name
ORM2
UniProt Synonym Gene Names
AGP2; AGP 2; OMD 2
UniProt Entry Name
A1AG2_HUMAN

NCBI Description

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

Uniprot Description

ORM2: Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction. Belongs to the calycin superfamily. Lipocalin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q32

Cellular Component: extracellular space

Biological Process: regulation of immune system process; transport; acute-phase response

Research Articles on AGP-2

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Product Notes

The AGP-2 orm2 (Catalog #AAA3006377) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AGP-2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's AGP-2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:1000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the AGP-2 orm2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AGP-2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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