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Western Blot (WB) (Western Blot analysis of Alpha-1 Acid Glycoprotein on human liver tissue lysates using anti-Alpha-1 acid glycoprotein antibody at 1/500 dilution.)

Rabbit ORM1 Polyclonal Antibody | anti-ORM1 antibody

ORM1 Polyclonal Antibody

Gene Names
ORM1; ORM; AGP1; AGP-A; HEL-S-153w
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, Flow Cytometry, Functional Assay
Purity
Protein affinity purified
Synonyms
ORM1; Polyclonal Antibody; ORM1 Polyclonal Antibody; AGP 1; OMD 1; AGP1; A1AG1; AGP A; AGP; Alpha 1 acid glycoprotein; Alpha-1-acid glycoprotein 1; alpha-1-AGP; Epididymis secretory sperm binding protein Li 153w; glycoprotein; alpha-1-acid; of serum; HEL S 153w; ORM; Orosomucoid 1; Orosomucoid-1; anti-ORM1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
ORM1 polyclonal antibody detects endogenous levels of ORM1 protein.
Purity/Purification
Protein affinity purified
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
201
Applicable Applications for anti-ORM1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
FC/FACS: 1:50-1:100
Immunogen
Recombinant protein
Preparation and Storage
Store at 4 degree C after thawing.
Aliquot store at -20 degree C or -80 degree C.
Avoid repeated freeze/thaw cycles.

Western Blot (WB)

(Western Blot analysis of Alpha-1 Acid Glycoprotein on human liver tissue lysates using anti-Alpha-1 acid glycoprotein antibody at 1/500 dilution.)

Western Blot (WB) (Western Blot analysis of Alpha-1 Acid Glycoprotein on human liver tissue lysates using anti-Alpha-1 acid glycoprotein antibody at 1/500 dilution.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Alpha-1 Acid Glycoprotein antibody. Counter stained with hematoxylin.)

Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Alpha-1 Acid Glycoprotein antibody. Counter stained with hematoxylin.)
Related Product Information for anti-ORM1 antibody
AGP (alpha1-acid glycoprotein) is an acute phase plasma protein synthesized by the liver. It functions to regulate the interaction between blood cells and endothelial cells, and together with haptoglobin and C reactive protein, it also mediates the extravasation of cells during infection and inflammation. Expression of AGP is induced by acute-phase stimulatory agents such as bacterial lipopolysaccharides. AGP has a high affinity, low capacity binding for basic drugs at physiological pH. In human plasma, AGP is found at levels of 0.5-1.4 mg/ml, though this is elevated during acute inflammation, and, as a result, levels of this protein can be used to identify inflammatory conditions. AGP-1 and AGP-2 contain five and six potential N-glycosylation sites, respectively. Abnormal expression of the APG-1 gene is linked to sarcoidosis and other immunogenetic diseases, while mutations in the APG-2 gene are associated with different types of carcinomas.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
35kDa
NCBI Official Full Name
Alpha-1-acid glycoprotein 1
NCBI Official Synonym Full Names
orosomucoid 1
NCBI Official Symbol
ORM1
NCBI Official Synonym Symbols
ORM; AGP1; AGP-A; HEL-S-153w
NCBI Protein Information
alpha-1-acid glycoprotein 1
UniProt Protein Name
Alpha-1-acid glycoprotein 1
Protein Family
UniProt Gene Name
ORM1
UniProt Synonym Gene Names
AGP1; AGP 1; OMD 1
UniProt Entry Name
A1AG1_HUMAN

NCBI Description

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

Uniprot Description

ORM1: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. Belongs to the calycin superfamily. Lipocalin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q32

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding

Biological Process: regulation of immune system process; transport; acute-phase response; inflammatory response

Research Articles on ORM1

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Product Notes

The ORM1 orm1 (Catalog #AAA3013174) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ORM1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ORM1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). WB: 1:500-1:2000 IHC: 1:50-1:200 FC/FACS: 1:50-1:100. Researchers should empirically determine the suitability of the ORM1 orm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ORM1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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