Western Blot (WB)
(Western Blot analysis of ACAN in L929 whole cell extracts using MBS6000465.)
Rabbit Aggrecan Neoepitope Polyclonal Antibody | anti-ADAMTS9 antibody
Aggrecan Neoepitope (Aggrecan Core Protein, Cartilage-specific Proteoglycan Core Protein, CSPCP, Chondroitin Sulfate Proteoglycan Core Protein 1, Chondroitin Sulfate Proteoglycan 1, AGC1, CSPG1, MSK16, ACAN)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: Immunofluorescence: 1ug/ml
Western Blot: 1ug/ml (band is detected at ~61kD representing the neoepitope sequence (NITEGE) generated by aggrecanase-mediated cleavage at Glu373-Ala374 of aggrecan core proteins)
Western Blot (WB)
(Western Blot analysis of ACAN in L929 whole cell extracts using MBS6000465.)
Western Blot (WB)
(Western Blot analysis of ACAN in L929 whole cell extracts using MBS6000465.)
Testing Data
(ACAN staining of OA cartilage using MBS6000465.)
Testing Data
(ACAN staining of OA cartilage using MBS6000465.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. [provided by RefSeq, Jul 2008]
Uniprot Description
ADAMTS9: Cleaves the large aggregating proteoglycans, aggrecan and versican. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.24.-; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Protease; Extracellular matrix
Chromosomal Location of Human Ortholog: 3p14.1
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; endoplasmic reticulum
Molecular Function: zinc ion binding; metallopeptidase activity; metalloendopeptidase activity
Biological Process: vesicle-mediated transport; protein transport; positive regulation of melanocyte differentiation; multicellular organismal development; glycoprotein catabolic process; proteolysis
Research Articles on ADAMTS9
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Product Notes
The ADAMTS9 adamts9 (Catalog #AAA6000465) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Aggrecan Neoepitope (Aggrecan Core Protein, Cartilage-specific Proteoglycan Core Protein, CSPCP, Chondroitin Sulfate Proteoglycan Core Protein 1, Chondroitin Sulfate Proteoglycan 1, AGC1, CSPG1, MSK16, ACAN) reacts with Bovine, Feline, Human, Mouse, Porcine, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Aggrecan Neoepitope can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Suitable for use in Immunofluorescence and Western Blot. Dilution: Immunofluorescence: 1ug/ml Western Blot: 1ug/ml (band is detected at ~61kD representing the neoepitope sequence (NITEGE) generated by aggrecanase-mediated cleavage at Glu373-Ala374 of aggrecan core proteins). Researchers should empirically determine the suitability of the ADAMTS9 adamts9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Aggrecan Neoepitope, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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