Western Blot (WB)
Rabbit AGE Polyclonal Antibody | anti-AGE antibody
AGE Antibody FITC-Conjugated
Reactivity
Bovine, Human, Monkey, Panda
Applications
ELISA, Western Blot
Synonyms
AGE; Polyclonal Antibody; AGE Antibody FITC-Conjugated; Advanced glycation end products; AGEs antibody; anti-AGE antibody
Host
Rabbit
Reactivity
Bovine, Human, Monkey, Panda
Clonality
Polyclonal
Form/Format
FITC-Conjugated
Concentration
0.55 ug/ul in antibody stabilization buffer (varies by lot)
Applicable Applications for anti-AGE antibody
ELISA (EIA), Western Blot (WB)
Application Notes
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500
ELISA: 1:10,000
Western Blot: 1:500
Immunogen
Purified glycated ribonuclease corresponding to AGE. Glycated ribonuclease (RNase) prepared by incubating RNase with glucose at 37 degree C for several months.
Expression
Endothelial cells.
Molecular Function
Inflammatory Response
Structure
Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.
Subcellular Location
Isoform 1 : Cell membrane; Single-pass type I membrane protein
Isoform 2 : Secreted
Isoform 10 : Cell membrane 1 Publication; Single-pass type I membrane protein
Isoform 2 : Secreted
Isoform 10 : Cell membrane 1 Publication; Single-pass type I membrane protein
Preparation and Storage
-20 degree C for long term storage
Western Blot (WB)
Western Blot (WB)
Related Product Information for anti-AGE antibody
FITC-Conjugated Advance Glycated Endproduct Antibody
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.
Similar Products
Product Notes
The AGE (Catalog #AAA540954) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AGE Antibody FITC-Conjugated reacts with Bovine, Human, Monkey, Panda and may cross-react with other species as described in the data sheet. AAA Biotech's AGE can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Western Blot: 1:500. Researchers should empirically determine the suitability of the AGE for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AGE, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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