Western Blot (WB)
(Anti- ADRB2 Picoband antibody, MBS177932, Western blottingAll lanes: AntiADRB2 (MBS177932) at 0.5ug/mlWB: Rat Brain Tissue Lysate at 50ugPredicted bind size: 47KDObserved bind size: 47KD )
ADRB2 Polyclonal Antibody | anti-ADRB2 antibody
Anti-ADRB2 Antibody
Predicted to work with: Human
Predicted to work with: Human
Western Blot (WB)
(Anti- ADRB2 Picoband antibody, MBS177932, Western blottingAll lanes: AntiADRB2 (MBS177932) at 0.5ug/mlWB: Rat Brain Tissue Lysate at 50ugPredicted bind size: 47KDObserved bind size: 47KD )
Western Blot (WB)
(Anti- ADRB2 Picoband antibody, MBS177932, Western blottingAll lanes: AntiADRB2 (MBS177932) at 0.5ug/mlWB: Rat Brain Tissue Lysate at 50ugPredicted bind size: 47KDObserved bind size: 47KD )
Background: ADRB2, also known as beta-2 adrenergic receptor, is a beta-adrenergic receptor within a cell membrane which reacts with adrenaline (epinephrine) as a hormone or neurotransmitter affecting muscles or organs. It is mapped to 5q32. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. The genetic variation in the ADRB2 gene may be of major importance for obesity, energy expenditure, and lipolytic ADRB2 function in adipose tissue, at least in women. What's more, it has been found that activation of ADRB2 receptors can stimulate gamma-secretase activity and beta-amyloid production, and the ADRB2 receptors activator may contribute to beta-amyloid accumulation in AD.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
Uniprot Description
ADRB2: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q31-q32
Cellular Component: apical plasma membrane; axon; caveola; dendritic spine; early endosome; endosome; integral to plasma membrane; lysosome; nucleus; plasma membrane; receptor complex; sarcolemma
Molecular Function: adenylate cyclase binding; B2 bradykinin receptor binding; beta2-adrenergic receptor activity; dopamine binding; drug binding; epinephrine binding; G-protein alpha-subunit binding; ionotropic glutamate receptor binding; norepinephrine binding; potassium channel regulator activity; protein binding; protein complex binding; protein homodimerization activity
Biological Process: adenylate cyclase activation; aging; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; associative learning; bone resorption; brown fat cell differentiation; cell surface receptor linked signal transduction; cell-cell signaling; diaphragm contraction; diet induced thermogenesis; endosome to lysosome transport; female pregnancy; G-protein signaling, coupled to cAMP nucleotide second messenger; heat generation; negative regulation of angiogenesis; negative regulation of inflammatory response; negative regulation of multicellular organism growth; negative regulation of ossification; negative regulation of smooth muscle contraction; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of apoptosis; positive regulation of ATPase activity; positive regulation of bone mineralization; positive regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of potassium ion transport; positive regulation of protein ubiquitination; positive regulation of skeletal muscle growth; positive regulation of the force of heart contraction by epinephrine; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vasodilation; receptor-mediated endocytosis; regulation of calcium ion transport; regulation of excitatory postsynaptic membrane potential; regulation of sensory perception of pain; response to cold; response to estrogen stimulus; response to progesterone stimulus; response to testosterone stimulus; synaptic transmission, glutamatergic; transmembrane receptor protein tyrosine kinase activation (dimerization); wound healing
Disease: Asthma, Susceptibility To; Obesity
Research Articles on ADRB2
Similar Products
Product Notes
The ADRB2 adrb2 (Catalog #AAA177932) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-ADRB2 Antibody reacts with Rat Predicted to work with: Human and may cross-react with other species as described in the data sheet. AAA Biotech's ADRB2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the ADRB2 adrb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADRB2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
