Rabbit ADRA1D Polyclonal Antibody | anti-ADRA1D antibody

Anti-ADRA1D Antibody

Cat. Num. AAA416711

• Gene Names: ADRA1D; DAR; ADRA1; ADRA1A; ADRA1R; ALPHA1; dJ779E11.2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Protein A purified
• Synonyms: ADRA1D; Polyclonal Antibody; Anti-ADRA1D Antibody; anti-ADRA1D antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ADRA1D antibody detects endogenous levels of total ADRA1D protein. Not tested with other proteins
• Purity/Purification: Protein A purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 572

• Applicable Applications for anti-ADRA1D antibody: Peptide ELISA (EIA), Western Blot (WB)
• Application Notes: Recommended dilutions:; Peptide ELISA: 1:8,000; WB: 1:200 - 1:1000; Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
• Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
• Immunogen: Synthetic peptide conjugated to KLH
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Western Blot (WB)

Related Product Information for anti-ADRA1D antibody

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties.

References

Schwinn,D.A.,Lomasney,J.W.,Lorenz,W.,et,al Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype

NCBI and Uniprot Product Information

• NCBI GI #: 4501957
• NCBI GeneID: 146
• NCBI Accession #: NP_000669.1
• NCBI GenBank Nucleotide #: NM_000678.3
• Molecular Weight: 60,463 Da
• NCBI Official Full Name: alpha-1D adrenergic receptor
• NCBI Official Synonym Full Names: adrenoceptor alpha 1D
• NCBI Official Symbol: ADRA1D
• NCBI Official Synonym Symbols: DAR; ADRA1; ADRA1A; ADRA1R; ALPHA1; dJ779E11.2
• NCBI Protein Information: alpha-1D adrenergic receptor; adrenergic, alpha -1D-, receptor; adrenergic, alpha-1A-, receptor; adrenergic, alpha-1D-, receptor; alpha-1A adrenergic receptor; alpha-1D adrenoceptor; alpha-1D adrenoreceptor; alpha-1D-adrenergic receptor; alpha-adrenergic receptor 1a
• UniProt Protein Name: Alpha-1D adrenergic receptor
• Protein Family: Alpha-1D adrenergic receptor
• UniProt Gene Name: ADRA1D
• UniProt Entry Name: ADA1D_HUMAN

NCBI Description

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]

Uniprot Description

ADRA1D: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: alpha1-adrenergic receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; cell proliferation; cell-cell signaling; multicellular organismal development; negative regulation of the force of heart contraction during baroreceptor response to increased systemic arterial blood pressure; positive regulation of cell proliferation; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; DNA metabolic process