Rabbit ADRA1A Polyclonal Antibody | anti-ADRA1A antibody

Rabbit Polyclonal to Human ADRA1A

Cat. Num. AAA247573

• Gene Names: ADRA1A; ADRA1C; ADRA1L1; ALPHA1AAR
• Reactivity: Bovine, Human, Monkey, Mouse, Rabbit, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: ADRA1A; Polyclonal Antibody; Rabbit Polyclonal to Human ADRA1A; Anti-ADRA1A Antibody IHC-plus; ADRA1L1; Adrenergic alpha 1c receptor; Alpha 1c adrenoceptor; Alpha-adrenergic receptor 1c; ADRA1C; Adrenoceptor alpha 1A; Alpha-1A adrenoceptor; Alpha-1A adrenoreceptor; Alpha-1A adrenergic receptor; Alpha-1C adrenergic receptor; ALPHA1AAR; Human ADRA1A; anti-ADRA1A antibody

• Host: Rabbit
• Reactivity: Bovine, Human, Monkey, Mouse, Rabbit, Rat
• Clonality: Polyclonal
• Specificity: Human Adrenergic receptor alpha 1a.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 466

• Applicable Applications for anti-ADRA1A antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (10 ug/ml), WB (1:500 - 1:3000); Usage: The antibody is predicted to cross-react with the following species based on their respective sequence homologies: mouse (100%), Rat (100%), Rabbit (100%), cow (100%), Monkey (100%. Cross-reactivity has not been experimentally confirmed at this time.
• Target Species: Human
• Immunogen Description: Synthetic peptide containing a sequence corresponding to a region within amino acids 206 and 270 of Human Alpha-1A adrenergic receptor.
• Immunogen Type: Synthetic peptide
• Immunogen: ADRA1A antibody was raised against synthetic peptide containing a sequence corresponding to a region within amino acids 206 and 270 of Human Alpha-1A adrenergic receptor.
• Preparation and Storage: Store at -20 degree C or lower. Aliquot to avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-ADRA1A antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Western Blot (WB)

(Sample(30 g of whole cell lysate). A: Raji. 10% SDS PAGE. ADRA1A antibody diluted at 1:1000.)

Related Product Information for anti-ADRA1A antibody

The alpha 1c- Adrenergic Receptor, also known as alpha 1a-adrenoceptor, is activated by epinephrine and norepinephrine. This receptor mediates calcium release upon ligand binding. The alpha 1-c adrenoceptor is one of three subtypes of alpha 1-adrenergic receptor (alpha 1 c/a, alpha 1b, and alpha 1d). The alpha 1c receptor couples to phospholipase C via a GTP-binding protein insensitive to pertussis toxin. Three isoforms are generated by alternative splicing.

Product Categories/Family for anti-ADRA1A antibody

Family: GPCR; Subfamily: Adrenergic

NCBI and Uniprot Product Information

• NCBI GI #: 111118992
• NCBI GeneID: 148
• NCBI Accession #: NP_000671.2
• NCBI GenBank Nucleotide #: NM_000680.2
• UniProt Accession #: P35348; O60451; Q13675; Q13729; A8K0I3; B0ZBD1; B0ZBD2; B0ZBD4; B0ZBD5; B0ZBD6; B0ZBD8; B0ZBD9
• Molecular Weight: 40,638 Da
• NCBI Official Full Name: alpha-1A adrenergic receptor isoform 1
• NCBI Official Synonym Full Names: adrenoceptor alpha 1A
• NCBI Official Symbol: ADRA1A
• NCBI Official Synonym Symbols: ADRA1C; ADRA1L1; ALPHA1AAR
• NCBI Protein Information: alpha-1A adrenergic receptor; alpha-1A adrenoceptor; alpha-1A adrenoreceptor; G protein coupled receptor; alpha-1C adrenergic receptor; adrenergic, alpha-1A-, receptor variant 1; adrenergic, alpha-1A-, receptor variant 3; adrenergic, alpha-1A-, receptor variant 5; adrenergic, alpha-1A-, receptor variant 8; adrenergic, alpha-1A-, receptor variant 11
• UniProt Protein Name: Alpha-1A adrenergic receptor
• Protein Family: Alpha-1A adrenergic receptor
• UniProt Gene Name: ADRA1A
• UniProt Synonym Gene Names: ADRA1C; Alpha-1A adrenoceptor
• UniProt Entry Name: ADA1A_HUMAN

NCBI Description

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

Uniprot Description

ADRA1A: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p21.2

Cellular Component: nuclear membrane; integral to plasma membrane; T-tubule; plasma membrane; Z disc; nucleus

Molecular Function: protein heterodimerization activity; alpha1-adrenergic receptor activity

Biological Process: apoptosis; response to hormone stimulus; positive regulation of systemic arterial blood pressure; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; signal transduction; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; smooth muscle contraction; positive regulation of MAPKKK cascade; cell-cell signaling; positive regulation of smooth muscle contraction; positive regulation of action potential; cell growth; aging; adult heart development; response to drug; positive regulation of the force of heart contraction by epinephrine-norepinephrine; positive regulation of synaptic transmission, GABAergic; micturition; negative regulation of heart rate in baroreceptor response to increased systemic arterial blood pressure; organ growth; G-protein coupled receptor protein signaling pathway; negative regulation of Rho protein signal transduction; phospholipase C activation; positive regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of heart rate by epinephrine-norepinephrine