Rabbit ADRA1A Polyclonal Antibody | anti-ADRA1A antibody

ADRA1A Polyclonal Antibody

Cat. Num. AAA2527716

• Gene Names: ADRA1A; ADRA1C; ADRA1L1; ALPHA1AAR
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: ADRA1A; Polyclonal Antibody; ADRA1A Polyclonal Antibody; ADRA1C; ADRA1L1; ALPHA1AAR; anti-ADRA1A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.4mg/mL (varies by lot)
• Sequence Length: 466

• Applicable Applications for anti-ADRA1A antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:200-1:1000; IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human ADRA1A
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of PC3, A549 and K562 cell using ADRA1A Polyclonal Antibody at dilution of 1:300)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer using ADRA1A Polyclonal Antibody at dilution of 1:40)

Related Product Information for anti-ADRA1A antibody

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties.

Product Categories/Family for anti-ADRA1A antibody

Epigenetics

NCBI and Uniprot Product Information

• NCBI GI #: 1168246
• NCBI GeneID: 148
• Molecular Weight: 40,638 Da
• NCBI Official Full Name: Alpha-1A adrenergic receptor
• NCBI Official Synonym Full Names: adrenoceptor alpha 1A
• NCBI Official Symbol: ADRA1A
• NCBI Official Synonym Symbols: ADRA1C; ADRA1L1; ALPHA1AAR
• NCBI Protein Information: alpha-1A adrenergic receptor; G protein coupled receptor; adrenergic, alpha-1A-, receptor variant 1; adrenergic, alpha-1A-, receptor variant 11; adrenergic, alpha-1A-, receptor variant 3; adrenergic, alpha-1A-, receptor variant 5; adrenergic, alpha-1A-, receptor variant 8; alpha-1A adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic receptor
• UniProt Protein Name: Alpha-1A adrenergic receptor
• Protein Family: Alpha-1A adrenergic receptor
• UniProt Gene Name: ADRA1A
• UniProt Synonym Gene Names: ADRA1C; Alpha-1A adrenoceptor
• UniProt Entry Name: ADA1A_HUMAN

NCBI Description

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

Uniprot Description

ADRA1A: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 8p21.2

Cellular Component: nuclear membrane; integral to plasma membrane; T-tubule; plasma membrane; Z disc; nucleus

Molecular Function: protein heterodimerization activity; alpha1-adrenergic receptor activity

Biological Process: apoptosis; response to hormone stimulus; positive regulation of systemic arterial blood pressure; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; signal transduction; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; smooth muscle contraction; positive regulation of MAPKKK cascade; cell-cell signaling; positive regulation of smooth muscle contraction; positive regulation of action potential; cell growth; aging; response to drug; adult heart development; positive regulation of the force of heart contraction by epinephrine-norepinephrine; positive regulation of synaptic transmission, GABAergic; micturition; G-protein coupled receptor protein signaling pathway; negative regulation of heart rate in baroreceptor response to increased systemic arterial blood pressure; organ growth; negative regulation of Rho protein signal transduction; phospholipase C activation; positive regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of heart rate by epinephrine-norepinephrine