Western Blot (WB)
(Western blot analysis of extracts of Mouse kidney, using ADM antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 15s.)
Rabbit anti-Human ADM Polyclonal Antibody | anti-ADM antibody
ADM Polyclonal Antibody
Western Blot (WB)
(Western blot analysis of extracts of Mouse kidney, using ADM antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 15s.)
Western Blot (WB)
(Western blot analysis of extracts of Mouse kidney, using ADM antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 15s.)
NCBI and Uniprot Product Information
Molecular Weight: 185
NCBI Description
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
Uniprot Description
ADM: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. Belongs to the adrenomedullin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: cytoplasm; cytosol; extracellular region; extracellular space
Molecular Function: adrenomedullin receptor binding; hormone activity; protein binding; receptor binding
Biological Process: aging; androgen metabolic process; antibacterial humoral response; antifungal humoral response; blood circulation; cAMP biosynthetic process; cAMP-mediated signaling; cell-cell signaling; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; developmental growth; elevation of cytosolic calcium ion concentration; female pregnancy; G-protein coupled receptor internalization; heart development; hormone secretion; negative regulation of cell proliferation; negative regulation of vascular permeability; negative regulation of vasoconstriction; neural tube closure; neurite regeneration; odontogenesis of dentine-containing teeth; organ regeneration; positive regulation of angiogenesis; positive regulation of apoptosis; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; positive regulation of heart rate; positive regulation of vasodilation; progesterone biosynthetic process; receptor internalization; regulation of the force of heart contraction; response to cold; response to glucocorticoid stimulus; response to hypoxia; response to insulin stimulus; response to lipopolysaccharide; response to starvation; response to wounding; response to yeast; signal transduction; vasculogenesis
Research Articles on ADM
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Product Notes
The ADM adm (Catalog #AAA9130045) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ADM Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ADM can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500 - 1:2000, IHC: 1:20 - 1:200. Researchers should empirically determine the suitability of the ADM adm for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADM, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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