Rabbit ADI1 Polyclonal Antibody | anti-ADI1 antibody

ADI1 Antibody

Cat. Num. AAA9611307

• Gene Names: ADI1; ARD; APL1; SIPL; mtnD; Fe-ARD; MTCBP1; Ni-ARD; HMFT1638
• Reactivity: Human; Mouse; Rat
• Applications: Western Blot
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: ADI1; Polyclonal Antibody; ADI1 Antibody; ADI1 Antibody - N-terminal; 1 2 dihydroxy 3 keto 5 methylthiopentene dioxygenase; 1; 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Aci reductone dioxygenase; Acireductone dioxygenase (Fe(2+) requiring); Acireductone dioxygenase (Ni(2+) requiring); Acireductone dioxygenase (Ni(2+)-requiring); Acireductone dioxygenase 1; ADI 1; Adi1; ADI1 antibody; APL1; ARD; EC 1.13.; Fe ARD; FLJ10913; HMFT1638; Membrane type 1 matrix metalloproteinase cytoplasmic tail binding protein 1; Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1; MT1 MMP cytoplasmic tail binding protein 1; MTCBP 1; MTCBP-1; MTCBP1; MTND_HUMAN; Ni-ARD; SIPL; Submergence induced protein 2; Submergence induced protein 2 homolog; Submergence induced protein like factor; Submergence-induced protein 2 homolog;; anti-ADI1 antibody

• Host: Rabbit
• Reactivity: Human; Mouse; Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ADI1 Antibody detects endogenous levels of ADI1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 179

• Applicable Applications for anti-ADI1 antibody: Western Blot (WB)
• Application Notes: WB 1:500-1:2000
• Immunogen: A synthesized peptide derived from human ADI1.
• Fragment: Fab fragment
• Conjugation: Unconjugated
• Storage Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C. Stable for 12 months from date of receipt.
• Preparation and Storage: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 degree C. Stable for 12 months from date of receipt.

Related Product Information for anti-ADI1 antibody

Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.

Similarity: Belongs to the acireductone dioxygenase (ARD) family.

NCBI and Uniprot Product Information

• NCBI GI #: 74733289
• NCBI GeneID: 55256
• UniProt Accession #: Q9BV57
• Molecular Weight: Observed Mol.Wt.: 20 kDa. Predicted Mol.Wt.: 22kDa.
• NCBI Official Full Name: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
• NCBI Official Synonym Full Names: acireductone dioxygenase 1
• NCBI Official Symbol: ADI1
• NCBI Official Synonym Symbols: ARD; APL1; SIPL; mtnD; Fe-ARD; MTCBP1; Ni-ARD; HMFT1638
• NCBI Protein Information: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
• UniProt Protein Name: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
• Protein Family: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
• UniProt Gene Name: ADI1
• UniProt Entry Name: MTND_HUMAN

NCBI Description

This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Uniprot Description

ADI1: Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. Belongs to the acireductone dioxygenase (ARD) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - cysteine and methionine; EC 1.13.11.54; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p25.3

Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: acireductone dioxygenase [iron(II)-requiring] activity; protein binding; iron ion binding; oxidoreductase activity

Biological Process: methionine salvage; sulfur amino acid metabolic process; polyamine metabolic process