Rabbit anti-Human ADGRE3 Polyclonal Antibody | anti-ADGRE3 antibody

ADGRE3 Rabbit pAb

Cat. Num. AAA4755032

• Gene Names: ADGRE3; EMR3
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: ADGRE3; Polyclonal Antibody; ADGRE3 Rabbit pAb; EMR3; anti-ADGRE3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Affinity purified
• Form/Format: -20 degree C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-ADGRE3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Synthetic peptide of human ADGRE3
• Conjugation: Unconjugated
• Molecular Function: This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Modification: Unmodified
• Cell Position: Cell membrane, Membrane, Secreted
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: Jurkat cell lysate, Primary antibody: 163779(ADGRE3 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute)

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 163779(ADGRE3 Antibody) at dilution 1/35. (Original magnification: ×200))

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 163779(ADGRE3 Antibody) at dilution 1/35. (Original magnification: ×200))

Product Categories/Family for anti-ADGRE3 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 133930786
• NCBI GeneID: 84658
• NCBI Accession #: NP_115960
• NCBI GenBank Nucleotide #: NM_032571.4
• UniProt Accession #: Q9BY15
• Molecular Weight: 73 kDa
• NCBI Official Full Name: adhesion G protein-coupled receptor E3 isoform 1
• NCBI Official Synonym Full Names: adhesion G protein-coupled receptor E3
• NCBI Official Symbol: ADGRE3
• NCBI Official Synonym Symbols: EMR3
• NCBI Protein Information: adhesion G protein-coupled receptor E3
• UniProt Protein Name: EGF-like module-containing mucin-like hormone receptor-like 3
• Protein Family: Adhesion G protein-coupled receptor
• UniProt Gene Name: EMR3
• UniProt Entry Name: EMR3_HUMAN

NCBI Description

This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

Uniprot Description

EMR3: Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes- derived macrophages and activated neutrophils. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: extracellular space; plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; calcium ion binding

Biological Process: G-protein coupled receptor protein signaling pathway