Naspm trihydrochloride, Inhibitor | Naspm, inhibitor

Naspm trihydrochloride

Cat. Num. AAA5753558

• Purity: 98.00%
• Synonyms: Naspm trihydrochloride; 1-Naphthylacetyl spermine trihydrochloride; Naspm; inhibitor

• Purity/Purification: 98.00%
• Form/Format: Solid. Powder

• Solubility: H2O: 50mg/mL (104.19mM) Need ultrasonic; DMSO: 6.4mg/mL (13.34mM) Need ultrasonic; (<1mg/ml refers to the product slightly soluble or insoluble)
• Formula: C22H37Cl3N4O
• SMILES: [H]Cl.[H]Cl.[H]Cl.O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1
• CAS Number: 1049731-36-3
• Target & IC50: Others
• In Vitro: NASPM selectively suppressed the inwardly rectifying and Ca(2+)-permeable AMPA receptors expressed in type II neurons. It had no effect on AMPA receptors in type I neurons. The blocking effect of NASPM on the Ca(2+)-permeable AMPA receptors was use and voltage-dependent. When the effect of NASPM reached a steady state, current responses induced by ionophoretic applications of kainate, a non-desensitizing agonist of AMPA receptors, in type II neurons were suppressed by NASPM in a dose-dependent manner at -60 mV (IC50 0.33microM, and Hill coefficient 0.94). The response to kainate recovered partially after washing out NASPM. NASPM did not affect the Ca(2+)-permeable AMPA receptors when the neuronal membrane was held at potentials more positive than +40 mV. Furthermore, the blockade by NASPM which was attained at negative potentials was transiently removed by shifting membrane potential to +60 mV for 5 s together with a single ionophoretic application of kainate.
• Preparation and Storage: Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent

Structure

Related Product Information for Naspm, inhibitor

Naspm trihydrochloride is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors.

References

Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.
Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.