Goat anti-Human Adenosine A2b receptor Polyclonal Antibody | anti-ADORA2B antibody

Adenosine A2b receptor (adenosine A2 beta Receptor, ADORA2B, HGNC:264, ADORA2, Netrin-1 Receptor)

Cat. Num. AAA619202

• Gene Names: ADORA2B; ADORA2
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Adenosine A2b receptor; Polyclonal Antibody; Adenosine A2b receptor (adenosine A2 beta Receptor; ADORA2B; HGNC:264; ADORA2; Netrin-1 Receptor); Anti -Adenosine A2b receptor (adenosine A2 beta Receptor; anti-ADORA2B antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human Adenosine A2 beta Receptor.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in 0.5 mg/ml tris-saline, 0.02% sodium azide, pH7.3, 0.5% BSA.

• Applicable Applications for anti-ADORA2B antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA: 1:4000
• Immunogen: Synthetic peptide corresponding to human Adenosine A2 beta Receptor.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-ADORA2B antibody

The purine nucleoside adenosine modulates diverse physiological functions including induction of sedation, vasodilatation, suppression of cardiac rate and contractility, neurotransmitter release, inhibition of platelet aggregation and lipolysis. Adenosine released from cells interacts with membrane receptors (adenosine receptors, ARs). Based upon, biochemical and pharmacological criteria, ARs have been classified into A1, A2a, A2b, and A3. The high affinity receptor A1 inhibits adenyl cyclase, whereas low affinity receptor A2a stimulates the cyclase via G proteins. A2a receptor is believed to cause vasorelaxation in coronary artery. Various, ARs and their subtypes have recently been cloned from several species. ARs belong to the superfamily of G-protein coupled receptors and predicted to contain 7 transmembrane domains. The N-termini are predicted to be extracellular and the C-termini cytoplasmic. There is an overall 30% homology among the four ARs. ARs are distributed throughout the body. Gene location of various ARs: A1 (Chromosome 1; q.31.3-32.2); A2a (Chromosome 22); A2b (Chromosome 17; p.11.2-12); A3 (Chromos.1).

Product Categories/Family for anti-ADORA2B antibody

Antibodies; Abs to Netrin

NCBI and Uniprot Product Information

• NCBI GI #: 178150
• NCBI GeneID: 136
• UniProt Accession #: P29275; Q2L7J7
• Molecular Weight: 36,333 Da
• NCBI Official Full Name: adenosine A2b receptor
• NCBI Official Synonym Full Names: adenosine A2b receptor
• NCBI Official Symbol: ADORA2B
• NCBI Official Synonym Symbols: ADORA2
• NCBI Protein Information: adenosine receptor A2b; OTTHUMP00000065212
• UniProt Protein Name: Adenosine receptor A2b
• Protein Family: Adenosine receptor
• UniProt Gene Name: ADORA2B
• UniProt Entry Name: AA2BR_HUMAN

NCBI Description

This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq]

Uniprot Description

ADORA2B: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 17p12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: adenosine receptor activity, G-protein coupled

Biological Process: relaxation of vascular smooth muscle; activation of MAPK activity; adenylate cyclase activation; positive regulation of interleukin-6 production; positive regulation of guanylate cyclase activity; positive regulation of mast cell degranulation; excretion; G-protein signaling, adenylate cyclase activating pathway; positive regulation of chemokine production; G-protein coupled receptor protein signaling pathway; positive regulation of chronic inflammatory response to non-antigenic stimulus; cellular response to extracellular stimulus; JNK cascade; cellular defense response; adenosine receptor signaling pathway