Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human brain tissue using ADCY5/6 antibody.)
Rabbit anti-Human ADCY5/6 Polyclonal Antibody | anti-ADCY5/6 antibody
ADCY5/6 Antibody
Immunofluorescence: 1:100~1:500
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human brain tissue using ADCY5/6 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human brain tissue using ADCY5/6 antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of HeLa cells, using ADCY5/6 antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of HeLa cells, using ADCY5/6 antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. [provided by RefSeq, May 2015]
Uniprot Description
ADCY6: a membrane-associated enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Expressed in normal thyroid and brain tissues, as well as some tumors; its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.
Protein type: Membrane protein, multi-pass; Lyase; Membrane protein, integral; Transporter; Adenylyl cyclase; Transporter, aquaporin family; Nucleotide Metabolism - purine; EC 4.6.1.1
Chromosomal Location of Human Ortholog: 12q12-q13
Cellular Component: membrane; integral to membrane; plasma membrane; cilium
Molecular Function: protein binding; metal ion binding; protein kinase binding; ATP binding; adenylate cyclase activity
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; G-protein signaling, adenylate cyclase activating pathway; synaptic transmission; phospholipase C activation; energy reserve metabolic process; dopamine receptor signaling pathway; renal water homeostasis; innate immune response; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; transmembrane transport
Disease: Lethal Congenital Contracture Syndrome 8
Research Articles on ADCY5/6
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Product Notes
The ADCY5/6 adcy6 (Catalog #AAA9412653) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ADCY5/6 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ADCY5/6 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunofluorescence (IF). Immunohistochemistry: 1:50~1:100 Immunofluorescence: 1:100~1:500. Researchers should empirically determine the suitability of the ADCY5/6 adcy6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADCY5/6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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