Rabbit ADCY4 Polyclonal Antibody | anti-ADCY4 antibody

ADCY4 Polyclonal Antibody

Cat. Num. AAA2519124

• Gene Names: ADCY4; AC4
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: ADCY4; Polyclonal Antibody; ADCY4 Polyclonal Antibody; AC4; anti-ADCY4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.1mg/mL (varies by lot)
• Sequence Length: 130

• Applicable Applications for anti-ADCY4 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Recombinant protein of human ADCY4
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ADCY4 Polyclonal Antibody at dilution 1:30)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ADCY4 Polyclonal Antibody at dilution 1:30)

Related Product Information for anti-ADCY4 antibody

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 34785029
• NCBI GeneID: 196883
• Molecular Weight: 46,245 Da
• NCBI Official Full Name: ADCY4 protein, partial
• NCBI Official Synonym Full Names: adenylate cyclase 4
• NCBI Official Symbol: ADCY4
• NCBI Official Synonym Symbols: AC4
• NCBI Protein Information: adenylate cyclase type 4; ATP pyrophosphate-lyase 4; adenylate cyclase type IV; adenylyl cyclase 4
• UniProt Protein Name: Adenylate cyclase type 4
• Protein Family: Adenylate cyclase
• UniProt Gene Name: ADCY4
• UniProt Entry Name: ADCY4_HUMAN

NCBI Description

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

Uniprot Description

ADCY4: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Protein type: EC 4.6.1.1; Membrane protein, multi-pass; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Transporter; Adenylyl cyclase; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: membrane; cytoplasm; dendrite; plasma membrane; integral to membrane

Molecular Function: protein binding; metal ion binding; ATP binding; adenylate cyclase activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; epidermal growth factor receptor signaling pathway; synaptic transmission; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; phospholipase C activation; water transport; activation of protein kinase A; energy reserve metabolic process; renal water homeostasis; innate immune response; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; signal transduction; G-protein signaling, adenylate cyclase activating pathway; transmembrane transport