Western Blot (WB)
(Western blot analysis of extracts from EC304, using ADAM9 Antibody. The lane on the left was treated with blocking peptide.Observed bands: 70 kDa.)
Rabbit ADAM9 Polyclonal Antibody | anti-ADAM9 antibody
ADAM9 Antibody
Predicted: Pig, Horse, Rabbit
Predicted: Pig, Horse, Rabbit
ELISA (Peptide): 1:20000-1:40000
Western Blot (WB)
(Western blot analysis of extracts from EC304, using ADAM9 Antibody. The lane on the left was treated with blocking peptide.Observed bands: 70 kDa.)
Western Blot (WB)
(Western blot analysis of extracts from EC304, using ADAM9 Antibody. The lane on the left was treated with blocking peptide.Observed bands: 70 kDa.)
Western Blot (WB)
(Western blot analysis of extracts of Mouse kidney tissue sample,using ADAM9 Antibody.)
Western Blot (WB)
(Western blot analysis of extracts of Mouse kidney tissue sample,using ADAM9 Antibody.)
Post Translational Modifications: Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9. Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA).
Subunit Structure: Interacts with SH3GL2 and SNX9 through its cytoplasmic tail (PubMed:10531379). Interacts with ITGA6.
NCBI and Uniprot Product Information
Predicted: 91 kDa
NCBI Description
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
Uniprot Description
ADAM9: Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP. Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Protease; Motility/polarity/chemotaxis; EC 3.4.24.-
Chromosomal Location of Human Ortholog: 8p11.22
Cellular Component: extracellular space; focal adhesion; cell surface; basolateral plasma membrane; cytoplasm; integral to membrane
Molecular Function: collagen binding; integrin binding; protein binding; protein kinase C binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; laminin binding; SH3 domain binding
Biological Process: integrin-mediated signaling pathway; positive regulation of keratinocyte migration; extracellular matrix organization and biogenesis; activation of MAPKK activity; cell-matrix adhesion; membrane protein ectodomain proteolysis; response to glucocorticoid stimulus; positive regulation of cell adhesion mediated by integrin; positive regulation of membrane protein ectodomain proteolysis; keratinocyte differentiation; response to manganese ion; collagen catabolic process; extracellular matrix disassembly; PMA-inducible membrane protein ectodomain proteolysis; monocyte activation; response to hydrogen peroxide; positive regulation of protein secretion; transforming growth factor beta receptor signaling pathway; cell-cell adhesion mediated by integrin; cell adhesion mediated by integrin; cell adhesion; response to calcium ion
Disease: Cone-rod Dystrophy 9
Research Articles on ADAM9
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Product Notes
The ADAM9 adam9 (Catalog #AAA9610847) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ADAM9 Antibody reacts with Human, Mouse, Rat Predicted: Pig, Horse, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's ADAM9 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Peptide ELISA (EIA). WB: 1:500-1:2000 ELISA (Peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the ADAM9 adam9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADAM9, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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