Rabbit anti-Human ACVRL1 / ALK1 Polyclonal Antibody | anti-ACVRL1 antibody

Rabbit Polyclonal to Human ACVRL1 / ALK1

Cat. Num. AAA243221

• Gene Names: ACVRL1; HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: ACVRL1 / ALK1; Polyclonal Antibody; Rabbit Polyclonal to Human ACVRL1 / ALK1; Anti-ACVRL1 / ALK1 Antibody IHC-plus; ACVRL1; ALK1; Activin receptor-like kinase 1; ALK-1; ACVRLK1; HHT; HHT2; SKR3; TSR-I; ORW2; Human ACVRL1; anti-ACVRL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human ACVRL1.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 503

• Applicable Applications for anti-ACVRL1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (20 ug/ml), WB (1:500 - 1:3000)
• Target Species: Human
• Immunogen Description: Synthetic peptide containing a sequence corresponding to a region within amino acids 441 and 503 of ACVRL1.
• Immunogen Type: Synthetic peptide
• Immunogen: ACVRL1 / ALK1 antibody was raised against synthetic peptide containing a sequence corresponding to a region within amino acids 441 and 503 of ACVRL1.
• Preparation and Storage: Store at -20 degree C or lower. Aliquot to avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-ALK-1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.)

Immunohistochemistry (IHC)

(Anti-ALK-1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.)

Western Blot (WB)

(Sample (20 ug of whole cell lysate). A: Hep G2 membrane extract. 7.5% SDS PAGE. Activin Type 2 Receptor antibody diluted at 1:5000.)

Related Product Information for anti-ACVRL1 antibody

Activin A receptor, type II-like 1 (also called activin receptor-like kinase 1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail.

Product Categories/Family for anti-ACVRL1 antibody

Family: Protein Kinase; Subfamily: Activin/TGFb

NCBI and Uniprot Product Information

• NCBI GI #: 116734712
• NCBI GeneID: 94
• NCBI Accession #: NP_000011.2
• NCBI GenBank Nucleotide #: NM_000020.2
• UniProt Accession #: P37023; A6NGA8
• Molecular Weight: 56,124 Da
• NCBI Official Full Name: serine/threonine-protein kinase receptor R3
• NCBI Official Synonym Full Names: activin A receptor type II-like 1
• NCBI Official Symbol: ACVRL1
• NCBI Official Synonym Symbols: HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1
• NCBI Protein Information: serine/threonine-protein kinase receptor R3; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 1
• UniProt Protein Name: Serine/threonine-protein kinase receptor R3
• Protein Family: Serine/threonine-protein kinase receptor
• UniProt Gene Name: ACVRL1
• UniProt Synonym Gene Names: ACVRLK1; ALK1; SKR3; ALK-1; TSR-I
• UniProt Entry Name: ACVL1_HUMAN

NCBI Description

This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]

Uniprot Description

ALK1: a kinase of the STKR family. A type I cell-surface receptor for the TGF-beta superfamily of ligands including Activin A. Highly expressed in human placenta and lung. Deficiency causes hemorrhagic telangiectasia type 2 also known as Rendu-Osler-Weber syndrome 2.

Protein type: Membrane protein, integral; Protein kinase, TKL; Kinase, protein; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cell surface; cell soma; integral to plasma membrane; dendrite

Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; activin receptor activity, type I; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; metal ion binding; activin binding; SMAD binding; protein kinase binding; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: protein heterooligomerization; blood circulation; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; negative regulation of cell adhesion; regulation of blood vessel endothelial cell migration; signal transduction; protein amino acid phosphorylation; BMP signaling pathway; negative regulation of cell proliferation; positive regulation of endothelial cell differentiation; negative regulation of endothelial cell differentiation; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; regulation of blood pressure; lymphangiogenesis; angiogenesis; negative regulation of cell migration; positive regulation of BMP signaling pathway; regulation of DNA replication; regulation of endothelial cell proliferation; in utero embryonic development; negative regulation of focal adhesion formation; negative regulation of blood vessel endothelial cell migration; blood vessel maturation; blood vessel endothelial cell proliferation during sprouting angiogenesis; positive regulation of angiogenesis; positive regulation of chondrocyte differentiation; negative regulation of endothelial cell proliferation; positive regulation of endothelial cell proliferation; blood vessel remodeling; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; wound healing, spreading of epidermal cells

Disease: Telangiectasia, Hereditary Hemorrhagic, Type 2