Western Blot (WB)
(Western Blot: Sample: Mouse Lung Tissue.)
Rabbit anti-Mouse Activating Transcription Factor 4 Polyclonal Antibody | anti-ATF4 antibody
Polyclonal Antibody to Activating Transcription Factor 4 (ATF4)
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Mouse Lung Tissue.)
Western Blot (WB)
(Western Blot: Sample: Mouse Lung Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant ATF4, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant ATF4, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Bowels tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Bowels tissue))
NCBI and Uniprot Product Information
Uniprot Description
ATF-4: a leucine zipper transcription factor that was isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). Involved in the unfolded protein response (UPR) in which dietary protein deficiency, imbalanced amino acid intake via the amino acid response, or ER stress activate the EIF2AK3-eIF2-ATF4 pathway. In concert with DDIT3, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors. Involved in cisplatin resistance. Other members of the family include AP-1 transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. A member of the bZIP family.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 15 E1|15 37.85 cM
Cellular Component: ATF1-ATF4 transcription factor complex; ATF4-CREB1 transcription factor complex; centrosome; CHOP-ATF4 complex; cytoplasm; cytoskeleton; Lewy body core; membrane; neuron projection; nuclear periphery; nucleus; plasma membrane; protein complex; transcription factor complex
Molecular Function: DNA binding; DNA binding transcription factor activity; leucine zipper domain binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase binding; sequence-specific DNA binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process: cellular response to amino acid starvation; cellular response to glucose starvation; circadian regulation of gene expression; circadian rhythm; gamma-aminobutyric acid signaling pathway; gluconeogenesis; mRNA transcription from RNA polymerase II promoter; negative regulation of potassium ion transport; PERK-mediated unfolded protein response; positive regulation of gene expression; positive regulation of neuron apoptotic process; positive regulation of transcription from RNA polymerase I promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription, DNA-templated; positive regulation of vascular endothelial growth factor production; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; rhythmic process; transcription, DNA-dependent
Research Articles on ATF4
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Product Notes
The ATF4 atf4 (Catalog #AAA2026391) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Activating Transcription Factor 4 (ATF4) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Activating Transcription Factor 4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-5ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the ATF4 atf4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Activating Transcription Factor 4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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