Rabbit anti-Human Acetyl-CoA acetyltransferase Polyclonal Antibody | anti-ACAT2 antibody

Rabbit anti-human Acetyl-CoA acetyltransferase, cytosolic polyclonal Antibody(ACAT2)

Cat. Num. AAA1494588

• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: Acetyl-CoA acetyltransferase; Polyclonal Antibody; Rabbit anti-human Acetyl-CoA acetyltransferase; cytosolic polyclonal Antibody(ACAT2); Recombinant human Acetyl-CoA acetyltransferase; cytosolic protein (1-97aa); Cytosolic acetoacetyl-CoA thiolase; ACAT2; ACTL; anti-ACAT2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Sequence Length: 426

• Applicable Applications for anti-ACAT2 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC:1:20-1:200
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Conjugate: Non-conjugated
• Immunogen: Recombinant human Acetyl-CoA acetyltransferase, cytosolic protein (1-97aa)
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-30279 / sc-30280
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human placenta using MBS1494588 at dilution 1:100)

Related Product Information for anti-ACAT2 antibody

Acetyl-CoA acetyltransferase 2 (ACAT2), also known as cytosolic acetoacetyl-CoA thiolase, plays a role in regulating lipid metabolism (1). It catalyzes the synthesis of acetoacetyl-CoA from two acetyl-CoA molecules, which is later converted into steroids (2).

NCBI and Uniprot Product Information

• NCBI GI #: 735997436
• NCBI GeneID: 39
• NCBI Accession #: NP_001290182.1
• NCBI GenBank Nucleotide #: NM_001303253.1
• UniProt Accession #: Q9BWD1; Q16146; Q5TCL7; Q8TDM4; B7Z233; E1P5B1
• Molecular Weight: 44,643 Da
• NCBI Official Full Name: acetyl-CoA acetyltransferase, cytosolic isoform 2
• NCBI Official Synonym Full Names: acetyl-CoA acetyltransferase 2
• NCBI Official Symbol: ACAT2
• NCBI Protein Information: acetyl-CoA acetyltransferase, cytosolic
• UniProt Protein Name: Acetyl-CoA acetyltransferase, cytosolic
• Protein Family: Acetyl-CoA acetyltransferase
• UniProt Gene Name: ACAT2
• UniProt Synonym Gene Names: ACTL
• UniProt Entry Name: THIC_HUMAN

NCBI Description

The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Uniprot Description

ACAT2: The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008]

Protein type: Lipid Metabolism - synthesis and degradation of ketone bodies; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - butanoate; EC 2.3.1.9; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - tryptophan; Acetyltransferase

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: cytoplasm; nucleolus; nucleus

Molecular Function: acetyl-CoA C-acetyltransferase activity; protein binding

Biological Process: lipid metabolic process

Disease: Acetyl-coa Acetyltransferase-2 Deficiency