ABHD2 Polyclonal Antibody | anti-ABHD2 antibody

ABHD2 Polyclonal Antibody

Cat. Num. AAA8521040

• Gene Names: ABHD2; HS1-2; LABH2; PHPS1-2
• Synonyms: ABHD2; Polyclonal Antibody; ABHD2 Polyclonal Antibody; anti-ABHD2 antibody

• Clonality: Polyclonal
• Sequence Length: 425

NCBI and Uniprot Product Information

• NCBI GI #: 23397659
• NCBI GeneID: 11057
• NCBI Accession #: NP_008942.3
• NCBI GenBank Nucleotide #: NM_007011.7
• UniProt Accession #: P08910; Q53G48; Q53GU0; Q5FVD9; Q8TC79
• Molecular Weight: 48,315 Da
• NCBI Official Full Name: monoacylglycerol lipase ABHD2
• NCBI Official Synonym Full Names: abhydrolase domain containing 2
• NCBI Official Symbol: ABHD2
• NCBI Official Synonym Symbols: HS1-2; LABH2; PHPS1-2
• NCBI Protein Information: monoacylglycerol lipase ABHD2
• UniProt Protein Name: Monoacylglycerol lipase ABHD2
• Protein Family: Monoacylglycerol lipase
• UniProt Gene Name: ABHD2

NCBI Description

This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a wide range of enzymes. The encoded protein is an acylglycerol lipase that catalyzes the hydrolysis of endocannabinoid arachidonoylglycerol from the cell membrane. This leads to activation of the sperm calcium channel CatSper, which results in sperm activation. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jan 2017]

Uniprot Description

Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration ().