Goat anti-Human ABCC4 Polyclonal Antibody | anti-ABCC4 antibody

ABCC4, CT (Multidrug Resistance-associated Protein 4, ATP-binding Cassette Sub-family C Member 4, MRP/cMOAT-related ABC transporter, Multi-specific Organic Anion Transporter B, MOAT-B, ABCC4)

Cat. Num. AAA6008188

• Gene Names: ABCC4; MRP4; MOATB; MOAT-B; EST170205
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: ABCC4; Polyclonal Antibody; CT (Multidrug Resistance-associated Protein 4; ATP-binding Cassette Sub-family C Member 4; MRP/cMOAT-related ABC transporter; Multi-specific Organic Anion Transporter B; MOAT-B; ABCC4); Anti -ABCC4; anti-ABCC4 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human ABCC4.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in tTBS, 0.02% sodium azide, pH 7.3, 0.5% BSA.

• Applicable Applications for anti-ABCC4 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:64,000; Immunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/ml
• Immunogen: Synthetic peptide corresponding to C-NGQPSTLTIFETAL of human ABCC4 at C-terminal.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Prostate (formalin-fixed, paraffin-embedded) stained with ABCC4 antibody at 2.5ug/ml followed by biotinylated goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-ABCC4 antibody

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.

Product Categories/Family for anti-ABCC4 antibody

Antibodies; Abs to Multi Drug Resistance (MDR)

NCBI and Uniprot Product Information

• NCBI GI #: 27371328
• NCBI GeneID: 10257
• UniProt Accession #: O15439; Q8IVZ4; Q8IZN6; Q8NEW8; Q9Y6J2; A9Z1Z7
• Molecular Weight: 149,527 Da
• NCBI Official Full Name: ABCC4 protein
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 4
• NCBI Official Symbol: ABCC4
• NCBI Official Synonym Symbols: MRP4; MOATB; MOAT-B; EST170205
• NCBI Protein Information: multidrug resistance-associated protein 4; MRP/cMOAT-related ABC transporter; multispecific organic anion transporter B; ATP-binding cassette sub-family C member 4; multi-specific organic anion transporter B; bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); canalicular multispecific organic anion transporter (ABC superfamily)
• UniProt Protein Name: Multidrug resistance-associated protein 4
• Protein Family: ABC transporter C family
• UniProt Gene Name: ABCC4
• UniProt Synonym Gene Names: MRP4; MOAT-B
• UniProt Entry Name: MRP4_HUMAN

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

ABCC4: a widely-expressed multi-pass membrane protein. An organic anion pump involved in cellular detoxification. Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 13q32

Cellular Component: membrane; basolateral plasma membrane; plasma membrane; integral to membrane; platelet dense granule membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; ATP binding

Biological Process: response to drug; platelet activation; platelet degranulation; positive regulation of smooth muscle cell proliferation; response to organic nitrogen; blood coagulation; transmembrane transport; response to organic cyclic substance